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• W2044511734 abstract "Abstract Introduction: Prenatal diagnosis of severe α‐ and β‐thalasssemia diseases is usually performed by DNA analysis. Objective: To establish a simple method, we have evaluated the reliability of prenatal diagnosis by fetal blood analysis using automated capillary electrophoresis system. Methods: Forty‐seven fetal blood specimens collected by cordocentesis at 18–28 wk of gestation were analyzed by the capillary electrophoresis system (Sebia). Fetal DNA was analyzed for respective thalassemia alleles by PCR. Results: Among 47 fetuses, 20 were at risk for the Hb Bart’s hydrops fetalis. DNA analysis identified four cases of homozygous α°‐thalassemia (SEA type). Hb analysis by the capillary electrophoresis demonstrated a major peak of Hb Bart’s (78.4–81.3%), Hb H (0.8–1.4%) and minor peaks of presumably embryonic Hbs. No Hb F and Hb A was observed. The level of Hb Bart’s was found to be 3.4–5.8% in unaffected heterozygote whereas normal fetus had no Hb Bart’s. Among the remaining 27 fetuses at risk for Hb E‐β‐thalassemia, DNA analysis identified 12 affected fetuses. Hb analysis showed Hb F (94.9–98.9%) and Hb E (1.1–1.8%) without Hb A in all cases. The levels of Hb A were found to be (4.3–7.2%), (1.0–5.5%) and (2.1–3.9%) in normal, heterozygous Hb E and heterozygous β‐thalassemia fetuses, respectively. Affected and unaffected fetuses could be easily distinguished. Conclusion: Capillary electrophoresis system is a simple and automated procedure for accurate prenatal diagnosis of severe thalassemia diseases which could readily be performed in routine setting." @default.
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• W2044511734 date "2009-06-10" @default.
• W2044511734 modified "2023-10-12" @default.
• W2044511734 title "Analysis of fetal blood using capillary electrophoresis system: a simple method for prenatal diagnosis of severe thalassemia diseases" @default.
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• W2044511734 doi "https://doi.org/10.1111/j.1600-0609.2009.01245.x" @default.
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