FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044513098> ?p ?o ?g. }

• W2044513098 abstract "Drug discovery in skin pharmacotherapy is an enormous, continually expanding field. Researchers are developing novel and sensitive pharmaceutical products and drugs that target specific receptors to elicit concerted and appropriate responses. The pigment-bearing cells called melanophores have a significant contribution to make in this field. Melanophores, which contain the dark brown or black pigment melanin, constitute an important class of chromatophores. They are highly specialized in the bidirectional and coordinated translocation of pigment granules when given an appropriate stimulus. The pigment granules can be stimulated to undergo rapid dispersion throughout the melanophores, making the cell appear dark, or to aggregate at the center, making the cell appear light. The major signals involved in pigment transport within the melanophores are dependent on a special class of cell surface receptors called G-protein-coupled receptors (GPCRs). Many of these receptors of adrenaline, acetylcholine, histamine, serotonin, endothelin and melatonin have been found on melanophores. They are believed to have clinical relevance to skin-related ailments and therefore have become targets for high throughput screening projects. The selective screening of these receptors requires the recognition of particular ligands, agonists and antagonists and the characterization of their effects on pigment motility within the cells. The mechanism of skin pigmentation is incredibly intricate, but it would be a considerable step forward to unravel its underlying physiological mechanism. This would provide an experimental basis for new pharmacotherapies for dermatological anomalies. The discernible stimuli that can trigger a variety of intracellular signals affecting pigment granule movement primarily include neurotransmitters and hormones. This review focuses on the role of the hormone and neurotransmitter signals involved in pigment movement in terms of the pharmacology of the specific receptors." @default.
• W2044513098 created "2016-06-24" @default.
• W2044513098 creator A5013958197 @default.
• W2044513098 creator A5076519281 @default.
• W2044513098 date "2011-01-01" @default.
• W2044513098 modified "2023-10-14" @default.
• W2044513098 title "Vertebrate melanophores as potential model for drug discovery and development: A review" @default.
• W2044513098 cites W1485475012 @default.
• W2044513098 cites W1498791370 @default.
• W2044513098 cites W1502817222 @default.
• W2044513098 cites W1511251378 @default.
• W2044513098 cites W1643675192 @default.
• W2044513098 cites W166672103 @default.
• W2044513098 cites W179646207 @default.
• W2044513098 cites W1910411491 @default.
• W2044513098 cites W1959837631 @default.
• W2044513098 cites W1964609983 @default.
• W2044513098 cites W1965516061 @default.
• W2044513098 cites W1967390278 @default.
• W2044513098 cites W1967501806 @default.
• W2044513098 cites W1969845496 @default.
• W2044513098 cites W1971837450 @default.
• W2044513098 cites W1972732140 @default.
• W2044513098 cites W1975119373 @default.
• W2044513098 cites W1975171976 @default.
• W2044513098 cites W1975181551 @default.
• W2044513098 cites W1977779600 @default.
• W2044513098 cites W1977861150 @default.
• W2044513098 cites W1977979647 @default.
• W2044513098 cites W1978029370 @default.
• W2044513098 cites W1978123979 @default.
• W2044513098 cites W1978774161 @default.
• W2044513098 cites W1979421801 @default.
• W2044513098 cites W1981605211 @default.
• W2044513098 cites W1982463365 @default.
• W2044513098 cites W1982527304 @default.
• W2044513098 cites W1982561710 @default.
• W2044513098 cites W1983963224 @default.
• W2044513098 cites W1984435786 @default.
• W2044513098 cites W1984491163 @default.
• W2044513098 cites W1987421668 @default.
• W2044513098 cites W1987802864 @default.
• W2044513098 cites W1987808660 @default.
• W2044513098 cites W1988495760 @default.
• W2044513098 cites W1989415091 @default.
• W2044513098 cites W1992543532 @default.
• W2044513098 cites W1993444428 @default.
• W2044513098 cites W1994979888 @default.
• W2044513098 cites W1995398602 @default.
• W2044513098 cites W1997026852 @default.
• W2044513098 cites W1998366703 @default.
• W2044513098 cites W2000260719 @default.
• W2044513098 cites W2003260981 @default.
• W2044513098 cites W2004305709 @default.
• W2044513098 cites W2004969297 @default.
• W2044513098 cites W2006443734 @default.
• W2044513098 cites W2006497644 @default.
• W2044513098 cites W2006775543 @default.
• W2044513098 cites W2008416814 @default.
• W2044513098 cites W2010633163 @default.
• W2044513098 cites W2011445209 @default.
• W2044513098 cites W2011984578 @default.
• W2044513098 cites W2013175456 @default.
• W2044513098 cites W2013771473 @default.
• W2044513098 cites W2014626482 @default.
• W2044513098 cites W2015099328 @default.
• W2044513098 cites W2015534806 @default.
• W2044513098 cites W2017338786 @default.
• W2044513098 cites W2018246654 @default.
• W2044513098 cites W2018970305 @default.
• W2044513098 cites W2019960280 @default.
• W2044513098 cites W2020046922 @default.
• W2044513098 cites W2020078623 @default.
• W2044513098 cites W2020201275 @default.
• W2044513098 cites W2020372381 @default.
• W2044513098 cites W2020746567 @default.
• W2044513098 cites W2022972927 @default.
• W2044513098 cites W2023652879 @default.
• W2044513098 cites W2024077591 @default.
• W2044513098 cites W2024937784 @default.
• W2044513098 cites W2025096776 @default.
• W2044513098 cites W2029082055 @default.
• W2044513098 cites W2029665825 @default.
• W2044513098 cites W2029914194 @default.
• W2044513098 cites W2029999575 @default.
• W2044513098 cites W2030557155 @default.
• W2044513098 cites W2033648907 @default.
• W2044513098 cites W2035839657 @default.
• W2044513098 cites W2037166494 @default.
• W2044513098 cites W2037745220 @default.
• W2044513098 cites W2038107128 @default.
• W2044513098 cites W2039680533 @default.
• W2044513098 cites W2040864077 @default.
• W2044513098 cites W2041150906 @default.
• W2044513098 cites W2042578571 @default.
• W2044513098 cites W2043112375 @default.
• W2044513098 cites W2043350804 @default.
• W2044513098 cites W2043584813 @default.
• W2044513098 cites W2043611293 @default.
• W2044513098 cites W2044066830 @default.

• next