FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044534387> ?p ?o ?g. }

• W2044534387 endingPage "200" @default.
• W2044534387 startingPage "191" @default.
• W2044534387 abstract "Studies have shown that seizures in young animals lead to later cognitive deficits. There is evidence that long-term potentiation (LTP) and long-term depression (LTD) might contribute to the neural basis for learning and memory mechanism and might be modulated by ATP and/or its dephosphorylated product adenosine produced by a cascade of cell-surface transmembrane enzymes, such as E-NTPDases (ecto-nucleoside triphosphate diphosphohydrolases) and ecto-5'-nucleotidase. Thus, we have investigated if hippocampal ecto-nucleotidase activities are altered at different time periods after one episode of seizure induced by kainic acid (KA) in 7 days old rats. We also have evaluated if 90 day-old rats previously submitted to seizure induced by KA at 7 days of age presented cognitive impairment in Y-maze behavior task. Our results have shown memory impairment of adult rats (Postnatal day 90) previously submitted to one single seizure episode in neonatal period (Postnatal day 7), which is accompanied by an increased ATP hydrolysis in hippocampal synaptosomes. The metabolism of ATP evaluated by HPLC confirmed that ATP hydrolysis was faster in adult rats treated with KA in neonatal period than in controls. Surprisingly, the mRNA and protein levels as seen by PCR and Western blot, respectively, were not altered by the KA administration in early age. Since we have found an augmented hydrolysis of ATP and this nucleotide seems to be important to LTP induction, we could assume that impairment of memory and learning observed in adult rats which have experienced a convulsive episode in postnatal period may be a consequence of the increased ATP hydrolysis. These findings correlate the purinergic signaling to the cognitive deficits induced by neonatal seizures and contribute to a better understanding about the mechanisms of seizure-induced memory dysfunction." @default.
• W2044534387 created "2016-06-24" @default.
• W2044534387 creator A5008213735 @default.
• W2044534387 creator A5012615383 @default.
• W2044534387 creator A5016013778 @default.
• W2044534387 creator A5046557952 @default.
• W2044534387 creator A5060940148 @default.
• W2044534387 creator A5068680303 @default.
• W2044534387 creator A5088021168 @default.
• W2044534387 creator A5088109532 @default.
• W2044534387 creator A5090314436 @default.
• W2044534387 date "2011-04-01" @default.
• W2044534387 modified "2023-09-26" @default.
• W2044534387 title "Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age" @default.
• W2044534387 cites W125666997 @default.
• W2044534387 cites W1603862527 @default.
• W2044534387 cites W1826983134 @default.
• W2044534387 cites W1964389840 @default.
• W2044534387 cites W1965280907 @default.
• W2044534387 cites W1967875018 @default.
• W2044534387 cites W1967952437 @default.
• W2044534387 cites W1971412104 @default.
• W2044534387 cites W1978705572 @default.
• W2044534387 cites W198961190 @default.
• W2044534387 cites W1994756644 @default.
• W2044534387 cites W1997774407 @default.
• W2044534387 cites W1998454224 @default.
• W2044534387 cites W1998708173 @default.
• W2044534387 cites W1999643558 @default.
• W2044534387 cites W2003444641 @default.
• W2044534387 cites W2006419030 @default.
• W2044534387 cites W2009140080 @default.
• W2044534387 cites W2009401980 @default.
• W2044534387 cites W2011391497 @default.
• W2044534387 cites W2018046195 @default.
• W2044534387 cites W2021544788 @default.
• W2044534387 cites W2024534565 @default.
• W2044534387 cites W2031556336 @default.
• W2044534387 cites W2039857567 @default.
• W2044534387 cites W2042913973 @default.
• W2044534387 cites W2043851570 @default.
• W2044534387 cites W2044030738 @default.
• W2044534387 cites W2045356884 @default.
• W2044534387 cites W2047591680 @default.
• W2044534387 cites W2051985836 @default.
• W2044534387 cites W2054278414 @default.
• W2044534387 cites W2056371509 @default.
• W2044534387 cites W2057994174 @default.
• W2044534387 cites W2069271283 @default.
• W2044534387 cites W2072621033 @default.
• W2044534387 cites W2075846042 @default.
• W2044534387 cites W2082539152 @default.
• W2044534387 cites W2088017716 @default.
• W2044534387 cites W2089413793 @default.
• W2044534387 cites W2092160846 @default.
• W2044534387 cites W2092240707 @default.
• W2044534387 cites W2095988220 @default.
• W2044534387 cites W2119185962 @default.
• W2044534387 cites W2134927362 @default.
• W2044534387 cites W2135810026 @default.
• W2044534387 cites W2139669380 @default.
• W2044534387 cites W2147075299 @default.
• W2044534387 cites W2147537019 @default.
• W2044534387 cites W2169798330 @default.
• W2044534387 cites W2171193971 @default.
• W2044534387 cites W4232534952 @default.
• W2044534387 cites W4293247451 @default.
• W2044534387 cites W74883566 @default.
• W2044534387 doi "https://doi.org/10.1016/j.neuroscience.2011.01.065" @default.
• W2044534387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21315806" @default.
• W2044534387 hasPublicationYear "2011" @default.
• W2044534387 type Work @default.
• W2044534387 sameAs 2044534387 @default.
• W2044534387 citedByCount "16" @default.
• W2044534387 countsByYear W20445343872012 @default.
• W2044534387 countsByYear W20445343872013 @default.
• W2044534387 countsByYear W20445343872015 @default.
• W2044534387 countsByYear W20445343872016 @default.
• W2044534387 countsByYear W20445343872018 @default.
• W2044534387 countsByYear W20445343872019 @default.
• W2044534387 countsByYear W20445343872020 @default.
• W2044534387 crossrefType "journal-article" @default.
• W2044534387 hasAuthorship W2044534387A5008213735 @default.
• W2044534387 hasAuthorship W2044534387A5012615383 @default.
• W2044534387 hasAuthorship W2044534387A5016013778 @default.
• W2044534387 hasAuthorship W2044534387A5046557952 @default.
• W2044534387 hasAuthorship W2044534387A5060940148 @default.
• W2044534387 hasAuthorship W2044534387A5068680303 @default.
• W2044534387 hasAuthorship W2044534387A5088021168 @default.
• W2044534387 hasAuthorship W2044534387A5088109532 @default.
• W2044534387 hasAuthorship W2044534387A5090314436 @default.
• W2044534387 hasBestOaLocation W20445343872 @default.
• W2044534387 hasConcept C126322002 @default.
• W2044534387 hasConcept C134018914 @default.
• W2044534387 hasConcept C148762608 @default.
• W2044534387 hasConcept C15744967 @default.
• W2044534387 hasConcept C169760540 @default.
• W2044534387 hasConcept C170493617 @default.

• next