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- W2044550073 abstract "Genetic sequence and hyper-methylation profile information from the promoter regions of tumor suppressor genes are important for cancer disease investigation. Since hyper-methylated DNA (hm-DNA) is typically present in ultra-low concentrations in biological samples, such as stool, urine, and saliva, sample enrichment and amplification is typically required before detection. We present a rapid microfluidic solid phase extraction (μSPE) system for the capture and elution of low concentrations of hm-DNA (≤1 ng ml−1), based on a protein-DNA capture surface, into small volumes using a passive microfluidic lab-on-a-chip platform. All assay steps have been qualitatively characterized using a real-time surface plasmon resonance (SPR) biosensor, and quantitatively characterized using fluorescence spectroscopy. The hm-DNA capture/elution process requires less than 5 min with an efficiency of 71% using a 25 μl elution volume and 92% efficiency using a 100 μl elution volume." @default.
- W2044550073 created "2016-06-24" @default.
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- W2044550073 date "2014-09-01" @default.
- W2044550073 modified "2023-10-05" @default.
- W2044550073 title "Rapid microfluidic solid-phase extraction system for hyper-methylated DNA enrichment and epigenetic analysis" @default.
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- W2044550073 doi "https://doi.org/10.1063/1.4899059" @default.
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