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- W2044558052 abstract "I ndirect evidence indicates that the rate‐limiting step in the synthesis of brain 5‐HT is the concentration of tryptophan in brain and not, as previously considered (G reen and S awyer , 1966), tryptophan hydroxylase. In fact this enzyme has a K m for its substrate much higher than the concentration of tryptophan normally present in the mammalian brain (J equier , L ovenberg and S joerdsma , 1967; J equier , R obinson , L ovesberg and S joerdsma , 1969; M cgeer , P eters and M cgeer , 1968). Tryptophan is the only amino acid circulating in plasma which is highly bound to serum proteins (M cmenamy and O ncley , 1958). We have previously shown that the free fraction of serum tryptophan controls the concentration of brain tryptophan and, therefore, 5‐HT synthesis as well (T agliamonte , B iggio and G essa , 1971d; G essa , B iggio and T agliamonte , 1972). Salicylate has been shown to displace tryptophan from its protein binding in plasma and to raise the free tryptophan concentration (M carthur and D awkins , 1969; S mith and L akatos , 1971). These considerations prompted us to study the effect of salicylate on tryptophan concentrations and 5‐HT metabolism in brain." @default.
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- W2044558052 date "1973-03-01" @default.
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- W2044558052 title "Increase of brain tryptophan and stimulation of serotonin synthesis by salicylate" @default.
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- W2044558052 doi "https://doi.org/10.1111/j.1471-4159.1973.tb00054.x" @default.
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