FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044562009> ?p ?o ?g. }

• W2044562009 endingPage "168" @default.
• W2044562009 startingPage "159" @default.
• W2044562009 abstract "Summary We recently separated a PG1828-encoded triacylated lipoprotein (Pg-LP), composed of two palmitoyl and one pentadecanoyl groups at the N-terminal of glycerocysteine from Porphyromonas gingivalis, a periodontopathic bacteria, and found that Pg-LP exhibited definite biological activities through Toll-like receptor (TLR) 2. In the present study, we synthesized 12 different Pg-LP N-terminal peptide moieties (PGTP) using four combinations of glyceryl (R and S) and cysteinyl (l and d) stereoisomers, and three different acyl group regioisomers, N-pentadecanoyl derivative (PGTP1), S-glycero 2-pentadecanoyl derivative (PGTP2) and S-glycero 3-pentadecanoyl derivative (PGTP3). All the PGTP compounds (RL, SL, SD, RD) tested showed TLR2-dependent cell activation. The activating capacities of the PGTP-R compounds were more potent than those of the PGTP-S compounds, whereas there were no differences between the PGTP-L and -D compounds. Furthermore, the production of interleukin (IL)-6 following stimulation with the PGTP1-RL, PGTP2-RL and PGTP3-RL compounds was impaired in peritoneal macrophages from TLR2 knock-out (KO), but not those from TLR1 KO or TLR6 KO mice. These results suggest that P. gingivalis triacylated lipopeptides are capable of activating host cells in a TLR2-dependent and TLR1-/TLR6-independent manner, and the fatty acid residue at the glycerol position in the PGTP molecule plays an important role in recognition by TLR2." @default.
• W2044562009 created "2016-06-24" @default.
• W2044562009 creator A5018568109 @default.
• W2044562009 creator A5028597074 @default.
• W2044562009 creator A5052642682 @default.
• W2044562009 creator A5074530644 @default.
• W2044562009 creator A5077599106 @default.
• W2044562009 creator A5086529614 @default.
• W2044562009 date "2006-08-25" @default.
• W2044562009 modified "2023-10-11" @default.
• W2044562009 title "Correlation between chemical structure and biological activities of <i>Porphyromonas gingivalis</i> synthetic lipopeptide derivatives" @default.
• W2044562009 cites W144506950 @default.
• W2044562009 cites W1768364851 @default.
• W2044562009 cites W1916851262 @default.
• W2044562009 cites W1964089999 @default.
• W2044562009 cites W1964604460 @default.
• W2044562009 cites W1969447989 @default.
• W2044562009 cites W2000582752 @default.
• W2044562009 cites W2004465286 @default.
• W2044562009 cites W2007098735 @default.
• W2044562009 cites W2008651707 @default.
• W2044562009 cites W2008853544 @default.
• W2044562009 cites W2019737761 @default.
• W2044562009 cites W2026975595 @default.
• W2044562009 cites W2027441758 @default.
• W2044562009 cites W2031643800 @default.
• W2044562009 cites W2044132116 @default.
• W2044562009 cites W2057809738 @default.
• W2044562009 cites W2080857291 @default.
• W2044562009 cites W2086271810 @default.
• W2044562009 cites W2089575955 @default.
• W2044562009 cites W2095833996 @default.
• W2044562009 cites W2096210882 @default.
• W2044562009 cites W2101363646 @default.
• W2044562009 cites W2114143997 @default.
• W2044562009 cites W2121797213 @default.
• W2044562009 cites W2128596600 @default.
• W2044562009 cites W2129319296 @default.
• W2044562009 cites W2130840482 @default.
• W2044562009 cites W2144868385 @default.
• W2044562009 cites W2145584783 @default.
• W2044562009 cites W2148579227 @default.
• W2044562009 cites W2151120686 @default.
• W2044562009 cites W2153382176 @default.
• W2044562009 cites W2156788946 @default.
• W2044562009 cites W2157107389 @default.
• W2044562009 cites W2157339124 @default.
• W2044562009 cites W2166078611 @default.
• W2044562009 cites W344561578 @default.
• W2044562009 doi "https://doi.org/10.1111/j.1365-2249.2006.03182.x" @default.
• W2044562009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809739" @default.
• W2044562009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16968410" @default.
• W2044562009 hasPublicationYear "2006" @default.
• W2044562009 type Work @default.
• W2044562009 sameAs 2044562009 @default.
• W2044562009 citedByCount "24" @default.
• W2044562009 countsByYear W20445620092012 @default.
• W2044562009 countsByYear W20445620092013 @default.
• W2044562009 countsByYear W20445620092014 @default.
• W2044562009 countsByYear W20445620092016 @default.
• W2044562009 countsByYear W20445620092017 @default.
• W2044562009 countsByYear W20445620092019 @default.
• W2044562009 countsByYear W20445620092020 @default.
• W2044562009 countsByYear W20445620092022 @default.
• W2044562009 countsByYear W20445620092023 @default.
• W2044562009 crossrefType "journal-article" @default.
• W2044562009 hasAuthorship W2044562009A5018568109 @default.
• W2044562009 hasAuthorship W2044562009A5028597074 @default.
• W2044562009 hasAuthorship W2044562009A5052642682 @default.
• W2044562009 hasAuthorship W2044562009A5074530644 @default.
• W2044562009 hasAuthorship W2044562009A5077599106 @default.
• W2044562009 hasAuthorship W2044562009A5086529614 @default.
• W2044562009 hasBestOaLocation W20445620092 @default.
• W2044562009 hasConcept C106159729 @default.
• W2044562009 hasConcept C111771559 @default.
• W2044562009 hasConcept C136449434 @default.
• W2044562009 hasConcept C162324750 @default.
• W2044562009 hasConcept C170493617 @default.
• W2044562009 hasConcept C185592680 @default.
• W2044562009 hasConcept C2777425210 @default.
• W2044562009 hasConcept C2779281246 @default.
• W2044562009 hasConcept C2780183776 @default.
• W2044562009 hasConcept C2781236682 @default.
• W2044562009 hasConcept C2781338088 @default.
• W2044562009 hasConcept C523546767 @default.
• W2044562009 hasConcept C54355233 @default.
• W2044562009 hasConcept C55493867 @default.
• W2044562009 hasConcept C71240020 @default.
• W2044562009 hasConcept C86803240 @default.
• W2044562009 hasConceptScore W2044562009C106159729 @default.
• W2044562009 hasConceptScore W2044562009C111771559 @default.
• W2044562009 hasConceptScore W2044562009C136449434 @default.
• W2044562009 hasConceptScore W2044562009C162324750 @default.
• W2044562009 hasConceptScore W2044562009C170493617 @default.
• W2044562009 hasConceptScore W2044562009C185592680 @default.
• W2044562009 hasConceptScore W2044562009C2777425210 @default.
• W2044562009 hasConceptScore W2044562009C2779281246 @default.
• W2044562009 hasConceptScore W2044562009C2780183776 @default.

• next