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- W2044562956 abstract "Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder that has very few effective therapeutic interventions. Since the disease has a defined neural circuitry abnormality, neuromodulation could be an option. Case reports, original research, and animal model studies were selected from the databases of Medline and PubMed. All related studies published up to July 2014 were included in this review. The following search terms were used: “Deep brain stimulation,” “DBS,” “thalamotomy,” “pallidal stimulation,” and “Huntington’s Disease,” “HD,” “chorea,” or “hyperkinetic movement disorders.” This review examines potential nodes in the HD circuitry that could be modulated using deep brain stimulation (DBS) therapy. With rapid evolution of imaging and ability to reach difficult targets in the brain with refined DBS technology, some phenotypes of HD could potentially be treated with DBS in the near future. Further clinical studies are warranted to validate the efficacy of neuromodulation and to determine the most optimal target for HD." @default.
- W2044562956 created "2016-06-24" @default.
- W2044562956 creator A5029752783 @default.
- W2044562956 creator A5070846785 @default.
- W2044562956 date "2015-05-01" @default.
- W2044562956 modified "2023-09-23" @default.
- W2044562956 title "Deep brain stimulation in Huntington’s disease: Assessment of potential targets" @default.
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- W2044562956 doi "https://doi.org/10.1016/j.jocn.2014.11.008" @default.
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