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- W2044570745 abstract "Brain metastasis occurs in 15–40% of cancer patients and is present in approximately 10–16% of patients with metastatic breast disease. However, little is known about prognostic factors enabling the early identification of breast cancer patients at risk of CNS metastases. Therapy for brain metastases should be based on several parameters, such as the assessment of prognostic variables, the extent of neurological and systemic disease, and its chemo-sensitivity to previously administered chemotherapy treatments. In view of the known close correlation between metastatic and primary tumor chemosensitivity, the type of chemotherapy chosen should depend more on the tumor histology than on the cerebral distribution of the single drug. More recent drugs with a high impact on the clinical outcome of metastatic breast cancer patients, such as taxanes or trastuzumab, play only a limited role in the treatment of brain metastases." @default.
- W2044570745 created "2016-06-24" @default.
- W2044570745 creator A5019091770 @default.
- W2044570745 creator A5033909956 @default.
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- W2044570745 date "2008-12-01" @default.
- W2044570745 modified "2023-09-29" @default.
- W2044570745 title "Chemotherapy in breast cancer patients with brain metastases: Have new chemotherapic agents changed the clinical outcome?" @default.
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- W2044570745 doi "https://doi.org/10.1016/j.critrevonc.2008.04.004" @default.
- W2044570745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18550383" @default.
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