FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044607507> ?p ?o ?g. }

• W2044607507 endingPage "797" @default.
• W2044607507 startingPage "785" @default.
• W2044607507 abstract "Commonly used inbred mouse strains display substantial differences in sensitivity to focal cerebral ischemia. Such differences can often be ascribed to differences in vascular anatomy. The authors investigated whether a contributing factor could be strain-related differences in cellular synthesis of the pleiotropic and potential neurotoxic cytokine tumor necrosis factor (TNF) in the border zone of and within the focal cerebral infarct. In all mouse strains investigated they found that TNF was synthesized by infarct and periinfarct infiltrating Mac-1 immunopositive microglia—macrophages. BALB/c mice, which developed the largest infarcts, contained significantly fewer TNF-producing microglia—macrophages compared with SJL and C57BL/6 mice at both 12 and 24 hours after permanent occlusion of the distal part of the middle cerebral artery. SJL mice developed larger infarcts than C57BL/6 mice, whereas the number of TNF-producing microglia—macrophages per infarct volume unit was comparable. Western blotting data confirmed the increased TNF levels in SJL mice compared with BALB/c and C57BL/6 mice. Furthermore, mice with 12-hour postischemic survival consistently contained two-to threefold more TNF-producing microglia—macrophages than mice with 24-hour survival. The data show that the magnitude of the cellular TNF response to cerebral ischemia is strain dependent, while the time-profile and the cellular sources of TNF are similar irrespective of genetic background. Furthermore, the lack of correlation between infarct size and cellular TNF response suggests that the functionally important TNF is produced in the very early phase (minutes to a few hours) after induction of ischemia, just as it raises the possibility that different mouse strains display different sensitivities to TNF." @default.
• W2044607507 created "2016-06-24" @default.
• W2044607507 creator A5018056521 @default.
• W2044607507 creator A5047153612 @default.
• W2044607507 creator A5064953301 @default.
• W2044607507 date "2002-07-01" @default.
• W2044607507 modified "2023-10-11" @default.
• W2044607507 title "Microglial—Macrophage Synthesis of Tumor Necrosis Factor after Focal Cerebral Ischemia in Mice is Strain Dependent" @default.
• W2044607507 cites W1517510044 @default.
• W2044607507 cites W1531571298 @default.
• W2044607507 cites W167428682 @default.
• W2044607507 cites W1969974084 @default.
• W2044607507 cites W1970703215 @default.
• W2044607507 cites W1974677157 @default.
• W2044607507 cites W1978869885 @default.
• W2044607507 cites W1982235788 @default.
• W2044607507 cites W1983051953 @default.
• W2044607507 cites W1996901446 @default.
• W2044607507 cites W1998005675 @default.
• W2044607507 cites W2005233270 @default.
• W2044607507 cites W2006862282 @default.
• W2044607507 cites W2006957980 @default.
• W2044607507 cites W2007281897 @default.
• W2044607507 cites W2017294185 @default.
• W2044607507 cites W2022378197 @default.
• W2044607507 cites W2024476573 @default.
• W2044607507 cites W2024868951 @default.
• W2044607507 cites W2026709325 @default.
• W2044607507 cites W2029883168 @default.
• W2044607507 cites W2034882426 @default.
• W2044607507 cites W2036344242 @default.
• W2044607507 cites W2038473458 @default.
• W2044607507 cites W2040957577 @default.
• W2044607507 cites W2046621497 @default.
• W2044607507 cites W2049521887 @default.
• W2044607507 cites W2053709527 @default.
• W2044607507 cites W2061642062 @default.
• W2044607507 cites W2061747759 @default.
• W2044607507 cites W2063504330 @default.
• W2044607507 cites W2063842801 @default.
• W2044607507 cites W2066991415 @default.
• W2044607507 cites W2069727032 @default.
• W2044607507 cites W2077680450 @default.
• W2044607507 cites W2082392406 @default.
• W2044607507 cites W2084473246 @default.
• W2044607507 cites W2090143569 @default.
• W2044607507 cites W2094009018 @default.
• W2044607507 cites W2094166208 @default.
• W2044607507 cites W2095572357 @default.
• W2044607507 cites W2111471304 @default.
• W2044607507 cites W2126289901 @default.
• W2044607507 cites W2140936548 @default.
• W2044607507 cites W2145070308 @default.
• W2044607507 cites W2153404483 @default.
• W2044607507 cites W2166138570 @default.
• W2044607507 cites W2168424667 @default.
• W2044607507 cites W231832547 @default.
• W2044607507 cites W2411960229 @default.
• W2044607507 cites W4294730393 @default.
• W2044607507 cites W4296025696 @default.
• W2044607507 doi "https://doi.org/10.1097/00004647-200207000-00004" @default.
• W2044607507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12142564" @default.
• W2044607507 hasPublicationYear "2002" @default.
• W2044607507 type Work @default.
• W2044607507 sameAs 2044607507 @default.
• W2044607507 citedByCount "60" @default.
• W2044607507 countsByYear W20446075072012 @default.
• W2044607507 countsByYear W20446075072013 @default.
• W2044607507 countsByYear W20446075072014 @default.
• W2044607507 countsByYear W20446075072015 @default.
• W2044607507 countsByYear W20446075072016 @default.
• W2044607507 countsByYear W20446075072018 @default.
• W2044607507 countsByYear W20446075072019 @default.
• W2044607507 countsByYear W20446075072021 @default.
• W2044607507 crossrefType "journal-article" @default.
• W2044607507 hasAuthorship W2044607507A5018056521 @default.
• W2044607507 hasAuthorship W2044607507A5047153612 @default.
• W2044607507 hasAuthorship W2044607507A5064953301 @default.
• W2044607507 hasBestOaLocation W20446075071 @default.
• W2044607507 hasConcept C104317684 @default.
• W2044607507 hasConcept C126322002 @default.
• W2044607507 hasConcept C142724271 @default.
• W2044607507 hasConcept C17991360 @default.
• W2044607507 hasConcept C202751555 @default.
• W2044607507 hasConcept C203014093 @default.
• W2044607507 hasConcept C2776914184 @default.
• W2044607507 hasConcept C2777928079 @default.
• W2044607507 hasConcept C2778690821 @default.
• W2044607507 hasConcept C2779244956 @default.
• W2044607507 hasConcept C2779830541 @default.
• W2044607507 hasConcept C503630168 @default.
• W2044607507 hasConcept C541997718 @default.
• W2044607507 hasConcept C55493867 @default.
• W2044607507 hasConcept C71924100 @default.
• W2044607507 hasConcept C76725341 @default.
• W2044607507 hasConcept C86803240 @default.
• W2044607507 hasConceptScore W2044607507C104317684 @default.
• W2044607507 hasConceptScore W2044607507C126322002 @default.

• next