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• W2044614458 abstract "To study effects of glycosaminoglycan on the interaction between two chain urokinase type plasminogen activator (tcu-PA) (EC 3.4.21.31) and plasminogen activator inhibitor type (PAI-1) the second order rate constant (k1) between high molecular weight tcu-PA and active recombinant prokaryotic PAI-1 (rpPAI-1) was determined employing a continuous method using chromogenic substrate S-2444 either in the presence or absence of various kinds of glycosaminoglycans. k1 was (5.9 ± 1.6) · 106/mol per s in the absence of effector molecule, and following addition of heparin (1.0 U/ml) k1 was enhanced to 3.22 ± 0.73) · 107. A significant enhancement of k1 was also obtained by heparan sulfate (1.87 ± 0.25) · 107. Dermatan sulfate or chondroitin sulfate did not show a significant effect of k1 although a slight decrease was obtained by mono-dextran sulfate (4.2 ± 1.2) · 106. The intrinsic fluorescence of rpPAI-1 was shown to be slightly increased following addition of heparin (1.49 ± 0.22%, n = 6), suggesting that heparin may enhance the inhibitory activity of PAI-1 toward tcy-PA both by a template mechanism and by a modification of PAI-1 structure." @default.
• W2044614458 created "2016-06-24" @default.
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• W2044614458 date "1994-11-11" @default.
• W2044614458 modified "2023-09-27" @default.
• W2044614458 title "Heparin and heparan sulfate enhancement of the inhibitory activity of plasminogen activator inhibitor type 1 toward urokinase type plasminogen activator" @default.
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• W2044614458 doi "https://doi.org/10.1016/0304-4165(94)90043-4" @default.
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