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• W2044641295 abstract "Erythropoietin (EPO) is a 31-kDa glycoprotein that has long been studied for its role in hematopoiesis. However, more recent evidence suggests that in addition to its biological functions in the hematopoietic system, EPO may have significant activity in the brain [ 1 Morishita E. Masuda S. Nagao M. Yasuda Y. Sasaki R. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience. 1997; 76: 105 Crossref PubMed Scopus (628) Google Scholar , 2 Marti H.H. Wenger R.H. Rivas L.A. et al. Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci. 1996; 8: 666 Crossref PubMed Scopus (498) Google Scholar , 3 Tan C.C. Eckardt K.U. Ratcliffe P.J. Organ distribution of erythropoietin messenger RNA in normal and uremic rats. Kidney Int. 1991; 40: 69 Crossref PubMed Scopus (102) Google Scholar ]. More specific functions in the brain have been proposed, including EPO as a neuroprotective agent against excitotoxicity and apopotosis, as well as EPO enhancing the proliferation and mobilization of neuronal stem cells [ 4 Gorio A. Gokmen N. Erbayraktar S. et al. Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci U S A. 2002; 99: 9450 Crossref PubMed Scopus (351) Google Scholar , 5 Digicaylioglu M. Lipton S.A. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. 2001; 412: 641 Crossref PubMed Scopus (867) Google Scholar ]. Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemiaJournal of Surgical ResearchVol. 183Issue 1PreviewSeptic encephalopathy is characterized by changes in mental status and an increase in neuronal apoptosis. Accumulating evidence has shown that recombinant human erythropoietin (rhEPO) protects brain against ischemia and hypoxia injury. However, whether rhEPO exerts neuroprotective effects on septic encephalopathy remains unclear. We designed the current study to evaluate possible neuroprotection of rhEPO in a model of sepsis. Full-Text PDF" @default.
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• W2044641295 date "2013-11-01" @default.
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• W2044641295 title "Importance of erythropoietin in septic encephalopathy" @default.
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• W2044641295 doi "https://doi.org/10.1016/j.jss.2013.01.043" @default.
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