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- W2044642912 abstract "Articular manifestations of systemic lupus erythematosus (SLE) include both small and large joints, the spine, and the complications associated with chronic steroid use such as osteonecrosis, osteoporosis, and stress fracture. Of the large joints, the knees, and of the small joints, the proximal interphalangeal joints of the hands are most commonly involved. Less frequently involved joints are the wrists, shoulders, ankles, and elbows. Periarticular symptoms can also be seen in SLE including enthesopathy, tenosynovitis, tendinopathy, and myositis as well as periarticular calcifications and nodules.Osteonecrosis of the hip, knee, shoulder or talus may affect up to 20% of patients with SLE. Although a given patient may have osteonecrosis at mulitple sites, the femoral head is most commonly affected and bilateral involvement is common. Because of its frequency and the significant disability that can result (particularly in the young lupus population), osteonecrosis is the articular manifestation of SLE with the most morbidity. Although the precise pathogenesis of osteonecrosis is unclear, it is clearly related to the use of corticosteroids. This chapter includes an in-depth discussion of the epidemeology, pathogenesis, diagnosis, and classification of osteonecrosis and reviews both operative and nonoperative treatment options." @default.
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- W2044642912 date "1974-09-01" @default.
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- W2044642912 title "Aseptic necrosis of bone in systemic lupus erythematosus" @default.
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- W2044642912 doi "https://doi.org/10.1016/0049-0172(74)90018-3" @default.
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