Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044646929> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2044646929 endingPage "130" @default.
- W2044646929 startingPage "126" @default.
- W2044646929 abstract "In an attempt to understand the role of free radicals in the regulation of sympathetic neurotransmission, the in vitro secretion of noradrenaline (NA) from synaptosomal preparations of guinea-pig ileum was investigated. Release of endogenous NA was quantified by an electrochemical detection (HPLC-ECD). In the presence of superoxide dismutase (SOD) and catalase at concentrations sufficient to scavenge the free radicals, secretion of NA was attenuated in samples with stimulation of 4-aminopyrine (4-AP) or not (spontaneous release). However, inducing superoxide radicals via the reaction of hypoxanthine with xanthine oxidase failed to modify the secretion of NA, both the 4-AP-stimulated release and the spontaneous secretion. Then, free radicals were induced in synaptosomes using hypoxia-normoxia exposure. Secretion of NA was markedly increased in samples receiving this treatment in a calcium-dependent way because it was attenuated by the removal of calcium chloride from bathing medium. An increase of SOD activity, both Mn-SOD and Cu, Zn-SOD, was also obtained by this exposure. Changes of SOD activities in response to free radicals produced by hypoxia-normoxia exposure in ileal synaptosomes can thus be considered. In conclusion, these results suggest that free radicals are formed to involve in the regulation of sympathetic neurotransmission via an increase of calcium influx to enhance the NA release in guinea-pig ileum." @default.
- W2044646929 created "2016-06-24" @default.
- W2044646929 creator A5041536120 @default.
- W2044646929 creator A5058371311 @default.
- W2044646929 date "1997-10-01" @default.
- W2044646929 modified "2023-10-17" @default.
- W2044646929 title "The role of free radicals in the release of noradrenaline from myenteric nerve terminals of guinea-pig ileum" @default.
- W2044646929 cites W1988147560 @default.
- W2044646929 cites W1988588954 @default.
- W2044646929 cites W2019912397 @default.
- W2044646929 cites W2024560631 @default.
- W2044646929 cites W2026071483 @default.
- W2044646929 cites W2034349574 @default.
- W2044646929 cites W2054977824 @default.
- W2044646929 cites W2059361117 @default.
- W2044646929 cites W2076272231 @default.
- W2044646929 cites W2078352358 @default.
- W2044646929 cites W2086610284 @default.
- W2044646929 cites W2095450169 @default.
- W2044646929 cites W2126564952 @default.
- W2044646929 cites W2127243011 @default.
- W2044646929 cites W2145026834 @default.
- W2044646929 cites W2169129605 @default.
- W2044646929 cites W2331476903 @default.
- W2044646929 cites W4293247451 @default.
- W2044646929 cites W4301108237 @default.
- W2044646929 doi "https://doi.org/10.1016/s0165-1838(97)00069-6" @default.
- W2044646929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9406115" @default.
- W2044646929 hasPublicationYear "1997" @default.
- W2044646929 type Work @default.
- W2044646929 sameAs 2044646929 @default.
- W2044646929 citedByCount "7" @default.
- W2044646929 countsByYear W20446469292016 @default.
- W2044646929 countsByYear W20446469292023 @default.
- W2044646929 crossrefType "journal-article" @default.
- W2044646929 hasAuthorship W2044646929A5041536120 @default.
- W2044646929 hasAuthorship W2044646929A5058371311 @default.
- W2044646929 hasConcept C126322002 @default.
- W2044646929 hasConcept C134018914 @default.
- W2044646929 hasConcept C139066938 @default.
- W2044646929 hasConcept C170493617 @default.
- W2044646929 hasConcept C178790620 @default.
- W2044646929 hasConcept C181199279 @default.
- W2044646929 hasConcept C185592680 @default.
- W2044646929 hasConcept C200170125 @default.
- W2044646929 hasConcept C2775838275 @default.
- W2044646929 hasConcept C2776151105 @default.
- W2044646929 hasConcept C2776219046 @default.
- W2044646929 hasConcept C2777226302 @default.
- W2044646929 hasConcept C2778102346 @default.
- W2044646929 hasConcept C2778815084 @default.
- W2044646929 hasConcept C2779470414 @default.
- W2044646929 hasConcept C2780795997 @default.
- W2044646929 hasConcept C519063684 @default.
- W2044646929 hasConcept C55493867 @default.
- W2044646929 hasConcept C71924100 @default.
- W2044646929 hasConcept C86803240 @default.
- W2044646929 hasConceptScore W2044646929C126322002 @default.
- W2044646929 hasConceptScore W2044646929C134018914 @default.
- W2044646929 hasConceptScore W2044646929C139066938 @default.
- W2044646929 hasConceptScore W2044646929C170493617 @default.
- W2044646929 hasConceptScore W2044646929C178790620 @default.
- W2044646929 hasConceptScore W2044646929C181199279 @default.
- W2044646929 hasConceptScore W2044646929C185592680 @default.
- W2044646929 hasConceptScore W2044646929C200170125 @default.
- W2044646929 hasConceptScore W2044646929C2775838275 @default.
- W2044646929 hasConceptScore W2044646929C2776151105 @default.
- W2044646929 hasConceptScore W2044646929C2776219046 @default.
- W2044646929 hasConceptScore W2044646929C2777226302 @default.
- W2044646929 hasConceptScore W2044646929C2778102346 @default.
- W2044646929 hasConceptScore W2044646929C2778815084 @default.
- W2044646929 hasConceptScore W2044646929C2779470414 @default.
- W2044646929 hasConceptScore W2044646929C2780795997 @default.
- W2044646929 hasConceptScore W2044646929C519063684 @default.
- W2044646929 hasConceptScore W2044646929C55493867 @default.
- W2044646929 hasConceptScore W2044646929C71924100 @default.
- W2044646929 hasConceptScore W2044646929C86803240 @default.
- W2044646929 hasIssue "3" @default.
- W2044646929 hasLocation W20446469291 @default.
- W2044646929 hasLocation W20446469292 @default.
- W2044646929 hasOpenAccess W2044646929 @default.
- W2044646929 hasPrimaryLocation W20446469291 @default.
- W2044646929 hasRelatedWork W1538952587 @default.
- W2044646929 hasRelatedWork W1993856947 @default.
- W2044646929 hasRelatedWork W201476708 @default.
- W2044646929 hasRelatedWork W2045943043 @default.
- W2044646929 hasRelatedWork W2079378515 @default.
- W2044646929 hasRelatedWork W2278900353 @default.
- W2044646929 hasRelatedWork W2335933507 @default.
- W2044646929 hasRelatedWork W2412975142 @default.
- W2044646929 hasRelatedWork W2473375054 @default.
- W2044646929 hasRelatedWork W4246884111 @default.
- W2044646929 hasVolume "66" @default.
- W2044646929 isParatext "false" @default.
- W2044646929 isRetracted "false" @default.
- W2044646929 magId "2044646929" @default.
- W2044646929 workType "article" @default.