Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044651251> ?p ?o ?g. }
- W2044651251 endingPage "e19823" @default.
- W2044651251 startingPage "e19823" @default.
- W2044651251 abstract "1-methyl-D-tryptophan (1-D-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors with the aim of inhibiting indoleamine-2,3-dioxygenase (IDO)-mediated tumor immune escape. IDO is expressed in tumors and tumor-draining lymph nodes and degrades tryptophan (trp) to create an immunsuppressive micromilieu both by depleting trp and by accumulating immunosuppressive metabolites of the kynurenine (kyn) pathway. Here we show that proliferation of alloreactive T-cells cocultured with IDO1-positive human cancer cells paradoxically was inhibited by 1-D-MT. Surprisingly incubation with 1-D-MT increased kyn production of human cancer cells. Cell-free assays revealed that 1-D-MT did not alter IDO1 enzymatic activity. Instead, 1-D-MT induced IDO1 mRNA and protein expression through pathways involving p38 MAPK and JNK signalling. Treatment of cancer patients with 1-D-MT has transcriptional effects that may promote rather than suppress anti-tumor immune escape by increasing IDO1 in the cancer cells. These off-target effects should be carefully analyzed in the ongoing clinical trials with 1-D-MT." @default.
- W2044651251 created "2016-06-24" @default.
- W2044651251 creator A5024826265 @default.
- W2044651251 creator A5039636827 @default.
- W2044651251 creator A5042378326 @default.
- W2044651251 creator A5063978061 @default.
- W2044651251 creator A5064778456 @default.
- W2044651251 creator A5071301453 @default.
- W2044651251 creator A5080482957 @default.
- W2044651251 creator A5086665191 @default.
- W2044651251 date "2011-05-20" @default.
- W2044651251 modified "2023-10-14" @default.
- W2044651251 title "The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells" @default.
- W2044651251 cites W1487098616 @default.
- W2044651251 cites W1505072916 @default.
- W2044651251 cites W1590342103 @default.
- W2044651251 cites W1964609124 @default.
- W2044651251 cites W1966082795 @default.
- W2044651251 cites W1970780414 @default.
- W2044651251 cites W1973251492 @default.
- W2044651251 cites W1990789246 @default.
- W2044651251 cites W1991344565 @default.
- W2044651251 cites W1996628160 @default.
- W2044651251 cites W1999601075 @default.
- W2044651251 cites W2003635644 @default.
- W2044651251 cites W2004528113 @default.
- W2044651251 cites W2005574379 @default.
- W2044651251 cites W2015260577 @default.
- W2044651251 cites W2026429388 @default.
- W2044651251 cites W2030410453 @default.
- W2044651251 cites W2030923896 @default.
- W2044651251 cites W2032731042 @default.
- W2044651251 cites W2049504854 @default.
- W2044651251 cites W2050779943 @default.
- W2044651251 cites W2053455572 @default.
- W2044651251 cites W2068834630 @default.
- W2044651251 cites W2070825197 @default.
- W2044651251 cites W2071514741 @default.
- W2044651251 cites W2075262140 @default.
- W2044651251 cites W2080889594 @default.
- W2044651251 cites W2090410108 @default.
- W2044651251 cites W2096891166 @default.
- W2044651251 cites W2096931514 @default.
- W2044651251 cites W2103092316 @default.
- W2044651251 cites W2111769244 @default.
- W2044651251 cites W2113846910 @default.
- W2044651251 cites W2122012981 @default.
- W2044651251 cites W2127191483 @default.
- W2044651251 cites W2127903252 @default.
- W2044651251 cites W2140881278 @default.
- W2044651251 cites W2150853783 @default.
- W2044651251 cites W2154879572 @default.
- W2044651251 doi "https://doi.org/10.1371/journal.pone.0019823" @default.
- W2044651251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3098827" @default.
- W2044651251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21625531" @default.
- W2044651251 hasPublicationYear "2011" @default.
- W2044651251 type Work @default.
- W2044651251 sameAs 2044651251 @default.
- W2044651251 citedByCount "122" @default.
- W2044651251 countsByYear W20446512512012 @default.
- W2044651251 countsByYear W20446512512013 @default.
- W2044651251 countsByYear W20446512512014 @default.
- W2044651251 countsByYear W20446512512015 @default.
- W2044651251 countsByYear W20446512512016 @default.
- W2044651251 countsByYear W20446512512017 @default.
- W2044651251 countsByYear W20446512512018 @default.
- W2044651251 countsByYear W20446512512019 @default.
- W2044651251 countsByYear W20446512512020 @default.
- W2044651251 countsByYear W20446512512021 @default.
- W2044651251 countsByYear W20446512512022 @default.
- W2044651251 countsByYear W20446512512023 @default.
- W2044651251 crossrefType "journal-article" @default.
- W2044651251 hasAuthorship W2044651251A5024826265 @default.
- W2044651251 hasAuthorship W2044651251A5039636827 @default.
- W2044651251 hasAuthorship W2044651251A5042378326 @default.
- W2044651251 hasAuthorship W2044651251A5063978061 @default.
- W2044651251 hasAuthorship W2044651251A5064778456 @default.
- W2044651251 hasAuthorship W2044651251A5071301453 @default.
- W2044651251 hasAuthorship W2044651251A5080482957 @default.
- W2044651251 hasAuthorship W2044651251A5086665191 @default.
- W2044651251 hasBestOaLocation W20446512511 @default.
- W2044651251 hasConcept C121608353 @default.
- W2044651251 hasConcept C126322002 @default.
- W2044651251 hasConcept C185592680 @default.
- W2044651251 hasConcept C203014093 @default.
- W2044651251 hasConcept C2776706248 @default.
- W2044651251 hasConcept C2776710720 @default.
- W2044651251 hasConcept C2777503454 @default.
- W2044651251 hasConcept C502942594 @default.
- W2044651251 hasConcept C515207424 @default.
- W2044651251 hasConcept C55493867 @default.
- W2044651251 hasConcept C71924100 @default.
- W2044651251 hasConcept C83478079 @default.
- W2044651251 hasConcept C86803240 @default.
- W2044651251 hasConcept C8891405 @default.
- W2044651251 hasConcept C96232424 @default.
- W2044651251 hasConceptScore W2044651251C121608353 @default.
- W2044651251 hasConceptScore W2044651251C126322002 @default.