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- W2044651570 abstract "Hydroxymethylglutaryl-coenzyme A inhibitors (HMG-CoA inhibitors, or statins) were initially identified as fungal extracts in 1976 (1). They were subsequently developed as cholesterol-lowering drugs, and have been shown in numerous clinical trials to reduce both cardiovascular morbidity and mortality (2–6). However, studies also revealed that statins yield a larger mortality benefit than can be readily explained by their cholesterol-lowering effects alone, since their benefits occur too quickly to be explained by effects on atherosclerotic plaque (7), and are greater than lipid-lowering alone would predict (8). Additionally, statins appear to have beneficial effects on human diseases, such as multiple sclerosis (MS) (9) and osteoporosis (10), that have no direct association with cholesterol levels. These findings, together with growing awareness that atherosclerosis is itself an inflammatory disease, led to the suggestion that, in addition to lowering cholesterol, statins modify atherosclerosis via antiinflammatory mechanisms. A broader hypothesis followed naturally: that statins might have general antiinflammatory and/or immunomodulatory effects. Research over the last 10 years has elucidated a number of mechanisms by which statins may exert antiinflammatory effects (7,11). In this article, we review the mechanisms of the action of statins, and the specific signaling pathways they modulate. We summarize the known potential antiinflammatory and immunomodulatory effects of statins at the cellular level. Finally, we review the data on the possible efficacy of statins in autoimmune/inflammatory diseases in both animal models and human trials." @default.
- W2044651570 created "2016-06-24" @default.
- W2044651570 creator A5019042456 @default.
- W2044651570 creator A5085768385 @default.
- W2044651570 date "2006-01-01" @default.
- W2044651570 modified "2023-10-14" @default.
- W2044651570 title "Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?" @default.
- W2044651570 cites W1479880028 @default.
- W2044651570 cites W1483753543 @default.
- W2044651570 cites W1486222787 @default.
- W2044651570 cites W1494502301 @default.
- W2044651570 cites W1506249422 @default.
- W2044651570 cites W1509483174 @default.
- W2044651570 cites W1525331105 @default.
- W2044651570 cites W1525488943 @default.
- W2044651570 cites W15429299 @default.
- W2044651570 cites W1871865728 @default.
- W2044651570 cites W1910601108 @default.
- W2044651570 cites W1953939137 @default.
- W2044651570 cites W1955146782 @default.
- W2044651570 cites W1963621262 @default.
- W2044651570 cites W1963913523 @default.
- W2044651570 cites W1966260445 @default.
- W2044651570 cites W1966760532 @default.
- W2044651570 cites W1966767094 @default.
- W2044651570 cites W1969555177 @default.
- W2044651570 cites W1970106273 @default.
- W2044651570 cites W1970844304 @default.
- W2044651570 cites W1971797638 @default.
- W2044651570 cites W1975307585 @default.
- W2044651570 cites W1977166847 @default.
- W2044651570 cites W1977595948 @default.
- W2044651570 cites W1978380407 @default.
- W2044651570 cites W1980857453 @default.
- W2044651570 cites W1985004174 @default.
- W2044651570 cites W1986949841 @default.
- W2044651570 cites W1987199103 @default.
- W2044651570 cites W1989014683 @default.
- W2044651570 cites W1989033619 @default.
- W2044651570 cites W1989198058 @default.
- W2044651570 cites W1989797372 @default.
- W2044651570 cites W1991230879 @default.
- W2044651570 cites W1991583073 @default.
- W2044651570 cites W1992540727 @default.
- W2044651570 cites W1993439431 @default.
- W2044651570 cites W1994884060 @default.
- W2044651570 cites W1994944734 @default.
- W2044651570 cites W1996279862 @default.
- W2044651570 cites W1999500196 @default.
- W2044651570 cites W2000643722 @default.
- W2044651570 cites W2000995578 @default.
- W2044651570 cites W2001615105 @default.
- W2044651570 cites W2002107594 @default.
- W2044651570 cites W2002474309 @default.
- W2044651570 cites W2004330500 @default.
- W2044651570 cites W2007087804 @default.
- W2044651570 cites W2007954685 @default.
- W2044651570 cites W2008797334 @default.
- W2044651570 cites W2011123221 @default.
- W2044651570 cites W2012887993 @default.
- W2044651570 cites W2014237668 @default.
- W2044651570 cites W2015143860 @default.
- W2044651570 cites W2017184181 @default.
- W2044651570 cites W2017662347 @default.
- W2044651570 cites W2017885661 @default.
- W2044651570 cites W2019731805 @default.
- W2044651570 cites W2020698032 @default.
- W2044651570 cites W2021314070 @default.
- W2044651570 cites W2021435938 @default.
- W2044651570 cites W2021690297 @default.
- W2044651570 cites W2022517233 @default.
- W2044651570 cites W2025016774 @default.
- W2044651570 cites W2027208842 @default.
- W2044651570 cites W2027810531 @default.
- W2044651570 cites W2028056878 @default.
- W2044651570 cites W2029020003 @default.
- W2044651570 cites W2029120648 @default.
- W2044651570 cites W2031334192 @default.
- W2044651570 cites W2033253411 @default.
- W2044651570 cites W2037198165 @default.
- W2044651570 cites W2039643538 @default.
- W2044651570 cites W2043746123 @default.
- W2044651570 cites W2046056065 @default.
- W2044651570 cites W2050392973 @default.
- W2044651570 cites W2055561625 @default.
- W2044651570 cites W2056530140 @default.
- W2044651570 cites W2059688582 @default.
- W2044651570 cites W2060774684 @default.
- W2044651570 cites W2060978652 @default.
- W2044651570 cites W2062423902 @default.
- W2044651570 cites W2062607383 @default.
- W2044651570 cites W2064042651 @default.
- W2044651570 cites W2065978890 @default.
- W2044651570 cites W2066040502 @default.
- W2044651570 cites W2067080563 @default.
- W2044651570 cites W2071035219 @default.
- W2044651570 cites W2072621393 @default.
- W2044651570 cites W2074996264 @default.