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- W2044652512 abstract "The mutagenic activity of: (1) 9-aminoacridine·HCl (AA), an acridine closely related to the acridine component of the acridine mustard, 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl]aminopropylamino) acridine·2 HCl (ICR-170); and (2) N-(2-chloroethyl)-N-ethyl-1,3-propylenediamine·2 HCl(ICR-177), the nitrogen mustard component of ICR-170, have been studied studied by inducing forward mutation at the ad−3 region of Neurospora crassa. The results indicate that AA is not mutagenic in the absence of visible light, whereas ICR-177 is mutagenic although it is a weak mutagen compared to ICR-170. The characterization of ad−3 mutants induced by ICR-177 shows that ICR-177 induces both multilocus deletions and intragenic alterations. The intragenic events include base-pair transitions, frameshift mutations, and possibly other changes. Hence, the potent multagenicity and mutagenic specificity of ICR-170 are due to the entire molecule and not to either the acridine or alkylating agent component. The mutagenic activity of ICR-177 appears to follow the mechanism proposed for monofunctional alkylating agents." @default.
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- W2044652512 date "1970-02-01" @default.
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- W2044652512 title "Characterization of ICR-177-induced ad-3 mutants of neurospora crassa" @default.
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- W2044652512 doi "https://doi.org/10.1016/0027-5107(70)90056-4" @default.
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