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• W2044654612 endingPage "2193" @default.
• W2044654612 startingPage "2189" @default.
• W2044654612 abstract "The site-specific recombinase encoded by the yeast plasmid 2-microns circle (FLP) forms a transient covalent linkage with its substrate DNA via a tyrosine residue, which appears to be located near its COOH terminus. The homology of the COOH terminus of FLP with that of the Int family of recombinases suggests that tyrosine-343 of FLP could be involved in forming the DNA-protein bridge. We have mutated tyrosine-343 to a phenylalanine or serine. We demonstrate that the binding of each of the two mutant proteins to its substrate is indistinguishable from that of wild-type FLP. However, both mutant proteins are incapable of catalyzing strand cleavage and recombination." @default.
• W2044654612 created "2016-06-24" @default.
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• W2044654612 date "1987-04-01" @default.
• W2044654612 modified "2023-10-14" @default.
• W2044654612 title "Mutations in the 2-microns circle site-specific recombinase that abolish recombination without affecting substrate recognition." @default.
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• W2044654612 doi "https://doi.org/10.1073/pnas.84.8.2189" @default.
• W2044654612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/304614" @default.
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