FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044657005> ?p ?o ?g. }

• W2044657005 endingPage "27" @default.
• W2044657005 startingPage "15" @default.
• W2044657005 abstract "Suppression of nuclear factor-κB (NF-κB)/inhibitor of nuclear factor-κB (IκB) signaling pathway is a potential property of thalidomide. This study was designed to investigate the effects of thalidomide on expressions of NF-κB, IκB and intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule (VCAM-1) in established rat liver cirrhosis. Rat liver cirrhosis was achieved by IP injection of carbon tetrachloride (CCl4) three times weekly for 8 weeks. CCl4 was then discontinued and thalidomide (100 mg/kg) or its vehicle was administered daily by gavage for 6 weeks. Hydroxyproline (HYP) content in liver was detected by biochemical assay. NF-κBp65, ICAM-1, VCAM-1 and α-smooth muscle actin (α-SMA) protein in the liver, IκBα protein in cytoplasm and NF-κBp65 protein in nucleus and ICAM-1, VCAM-1 mRNA levels in the liver were studied using immunohistochemistry, Western blot, and reverse transcriptase polymerase chain reaction, respectively. Compared with the spontaneous recovery of cirrhosis, the histopathology of liver of rats given thalidomide was significantly improved. HYP content in liver, the expressions of ICAM-1, VCAM-1 mRNA and protein, NF-κBp65 and α-SMA protein were decreased significantly and IκBα protein in liver was elevated significantly in this group. Thalidomide may exert its effect on downregulation of NF-κB-induced adhesion molecules and activation of hepatic stellate cell via inhibition of degradation of IκB to reverse established rat hepatic cirrhosis." @default.
• W2044657005 created "2016-06-24" @default.
• W2044657005 creator A5014805551 @default.
• W2044657005 creator A5024577852 @default.
• W2044657005 creator A5043684819 @default.
• W2044657005 creator A5047690802 @default.
• W2044657005 creator A5071809656 @default.
• W2044657005 creator A5073682120 @default.
• W2044657005 creator A5090691776 @default.
• W2044657005 date "2007-01-01" @default.
• W2044657005 modified "2023-10-17" @default.
• W2044657005 title "Reversal Effect of Thalidomide on Established Hepatic Cirrhosis in Rats via Inhibition of Nuclear Factor-κB/Inhibitor of Nuclear Factor-κB Pathway" @default.
• W2044657005 cites W103619855 @default.
• W2044657005 cites W1212464357 @default.
• W2044657005 cites W1491499843 @default.
• W2044657005 cites W1516207283 @default.
• W2044657005 cites W1969806734 @default.
• W2044657005 cites W1971578691 @default.
• W2044657005 cites W1975655020 @default.
• W2044657005 cites W1979372049 @default.
• W2044657005 cites W1982278353 @default.
• W2044657005 cites W1983347726 @default.
• W2044657005 cites W1983422438 @default.
• W2044657005 cites W1989644817 @default.
• W2044657005 cites W2005025375 @default.
• W2044657005 cites W2005391359 @default.
• W2044657005 cites W2016498524 @default.
• W2044657005 cites W2045273331 @default.
• W2044657005 cites W2046242609 @default.
• W2044657005 cites W2049714321 @default.
• W2044657005 cites W2067161281 @default.
• W2044657005 cites W2085110244 @default.
• W2044657005 cites W2093544430 @default.
• W2044657005 cites W2094133741 @default.
• W2044657005 cites W2094591634 @default.
• W2044657005 cites W2095412079 @default.
• W2044657005 cites W2095462726 @default.
• W2044657005 cites W2111796536 @default.
• W2044657005 cites W2113296405 @default.
• W2044657005 cites W2115956200 @default.
• W2044657005 cites W2141071175 @default.
• W2044657005 cites W2145028653 @default.
• W2044657005 cites W2161803404 @default.
• W2044657005 cites W4211136726 @default.
• W2044657005 cites W2065516583 @default.
• W2044657005 doi "https://doi.org/10.1016/j.arcmed.2006.09.006" @default.
• W2044657005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17174718" @default.
• W2044657005 hasPublicationYear "2007" @default.
• W2044657005 type Work @default.
• W2044657005 sameAs 2044657005 @default.
• W2044657005 citedByCount "27" @default.
• W2044657005 countsByYear W20446570052012 @default.
• W2044657005 countsByYear W20446570052013 @default.
• W2044657005 countsByYear W20446570052014 @default.
• W2044657005 countsByYear W20446570052015 @default.
• W2044657005 countsByYear W20446570052016 @default.
• W2044657005 countsByYear W20446570052017 @default.
• W2044657005 countsByYear W20446570052021 @default.
• W2044657005 crossrefType "journal-article" @default.
• W2044657005 hasAuthorship W2044657005A5014805551 @default.
• W2044657005 hasAuthorship W2044657005A5024577852 @default.
• W2044657005 hasAuthorship W2044657005A5043684819 @default.
• W2044657005 hasAuthorship W2044657005A5047690802 @default.
• W2044657005 hasAuthorship W2044657005A5071809656 @default.
• W2044657005 hasAuthorship W2044657005A5073682120 @default.
• W2044657005 hasAuthorship W2044657005A5090691776 @default.
• W2044657005 hasConcept C104317684 @default.
• W2044657005 hasConcept C126322002 @default.
• W2044657005 hasConcept C134018914 @default.
• W2044657005 hasConcept C134659918 @default.
• W2044657005 hasConcept C1491633281 @default.
• W2044657005 hasConcept C16224149 @default.
• W2044657005 hasConcept C176891718 @default.
• W2044657005 hasConcept C178790620 @default.
• W2044657005 hasConcept C185592680 @default.
• W2044657005 hasConcept C203014093 @default.
• W2044657005 hasConcept C2776364478 @default.
• W2044657005 hasConcept C2776415932 @default.
• W2044657005 hasConcept C2777214474 @default.
• W2044657005 hasConcept C2777359374 @default.
• W2044657005 hasConcept C2777730290 @default.
• W2044657005 hasConcept C2779609412 @default.
• W2044657005 hasConcept C55493867 @default.
• W2044657005 hasConcept C62478195 @default.
• W2044657005 hasConcept C71924100 @default.
• W2044657005 hasConcept C85789140 @default.
• W2044657005 hasConcept C86803240 @default.
• W2044657005 hasConceptScore W2044657005C104317684 @default.
• W2044657005 hasConceptScore W2044657005C126322002 @default.
• W2044657005 hasConceptScore W2044657005C134018914 @default.
• W2044657005 hasConceptScore W2044657005C134659918 @default.
• W2044657005 hasConceptScore W2044657005C1491633281 @default.
• W2044657005 hasConceptScore W2044657005C16224149 @default.
• W2044657005 hasConceptScore W2044657005C176891718 @default.
• W2044657005 hasConceptScore W2044657005C178790620 @default.
• W2044657005 hasConceptScore W2044657005C185592680 @default.
• W2044657005 hasConceptScore W2044657005C203014093 @default.
• W2044657005 hasConceptScore W2044657005C2776364478 @default.

• next