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• W2044657425 abstract "A direct chromogenic peptide substrate assay for Hageman factor (FXII) has been developed using a novel soluble activator of FXII. In this assay, plasma samples are treated with acetone to destroy plasma inhibitors of α and β FXIIa and diluted with methylamine-containing buffer to block enzyme binding sites on α 2 -macroglobulin. Following incubation for 10 minutes at 37°C with the FXII activator and the addition of buffer containing kallikrein inhibitor, the FXIla activities generated are detected by recording the release of pNA from the chromogenic peptide substrate S-2222. Analysis of plasma fractions in the assay (obtained by Sephadex G-150 gel filtration) revealed a major peak which yielded activity on activation. This peak corresponded with peak levels of FXII antigen and eluted at a molecular weight of approximately 80 000. The activity generated could be inhibited by corn inhibitor. Comparative studies with normal and FXII-deficient plasmas in this assay and a clotting assay resulted in a good correlation between the two assays." @default.
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• W2044657425 date "1987-04-01" @default.
• W2044657425 modified "2023-09-26" @default.
• W2044657425 title "A direct cbromogenic peptide substrate assay for hageman factor (FXII)" @default.
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• W2044657425 doi "https://doi.org/10.1016/0268-9499(87)90020-8" @default.
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