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- W2044657599 abstract "Objective: The history of the discovery of mechanisms contributing to sex difference helps to better appreciate gender factors in a variety of disease states. The objective of this article is to illustrate four mechanisms of sex differences in disease incidence: X-linkage (including inactivation, escape from inactivating, skewed inactivation), sex-specific exposure to disease-producing pathogens, fetal microchimerism, and iron depletion. Methods: This is a historic review. Results: An emphasis on sex difference led to the uncovering of four different mechanisms by which illness rates differ in men and women. Conclusions: Research into many disease states can benefit from a focus on potential mechanisms that yield sex differences in illness susceptibility, progression, and outcome." @default.
- W2044657599 created "2016-06-24" @default.
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- W2044657599 date "2009-06-01" @default.
- W2044657599 modified "2023-10-16" @default.
- W2044657599 title "Mechanisms of Sex Difference: A Historical Perspective" @default.
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- W2044657599 doi "https://doi.org/10.1089/jwh.2008.1208" @default.
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