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- W2044657834 abstract "Control of glyceraldehyde-3-phosphate dehydrogenase from heart muscle was similar to that of glyceraldehyde-3-phosphate dehydrogenase isolated from other tissues. Activity of the enzyme was greatly reduced by lowering pH from 7.0 to 6.5. NADH and ATP were both strong inhibitors. Inorganic phosphate stimulated glyceraldehyde-3-phosphate dehydrogenase activity and the ATP inhibition could be completely relieved by inorganic phosphate. NADH inhibition was only partially relieved by inorganic phosphate. Lactate at 20 mm inhibited activity of the enzyme by about 50% at cellular concentrations of glyceraldehyde-3-phosphate. Creatine phosphate was only weakly inhibitory. In ischemic hearts, glycolysis is inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. It is concluded that this inhibition can be accounted for by accumulation of H+, NADH and lactate in the ischemic tissue. Either factor alone may be capable of producing glycolytic inhibition, but the combined effect of these three inhibitors probably accounts for the inhibition that is observed." @default.
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- W2044657834 date "1979-03-01" @default.
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- W2044657834 title "Control of glyceraldehyde-3-phosphate dehydrogenase in cardiac muscle" @default.
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- W2044657834 doi "https://doi.org/10.1016/0022-2828(79)90437-1" @default.
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