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• W2044667557 abstract "A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy." @default.
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• W2044667557 date "2012-05-01" @default.
• W2044667557 modified "2023-10-18" @default.
• W2044667557 title "Novel triazolopyridylbenzamides as potent and selective p38α inhibitors" @default.
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• W2044667557 doi "https://doi.org/10.1016/j.bmcl.2012.03.099" @default.
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