FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044671396> ?p ?o ?g. }

• W2044671396 endingPage "e17028" @default.
• W2044671396 startingPage "e17028" @default.
• W2044671396 abstract "Epithelial homeostasis incorporates the paradoxical concept of internal change (epithelial turnover) enabling the maintenance of anatomical status quo. Epithelial cell differentiation and cell loss (cell shedding and apoptosis) form important components of epithelial turnover. Although the mechanisms of cell loss are being uncovered the crucial triggers that modulate epithelial turnover through regulation of cell loss remain undetermined. Serotonin is emerging as a common autocrine-paracine regulator in epithelia of multiple organs, including the breast. Here we address whether serotonin affects epithelial turnover. Specifically, serotonin's roles in regulating cell shedding, apoptosis and barrier function of the epithelium. Using in vivo studies in mouse and a robust model of differentiated human mammary duct epithelium (MCF10A), we show that serotonin induces mammary epithelial cell shedding and disrupts tight junctions in a reversible manner. However, upon sustained exposure, serotonin induces apoptosis in the replenishing cell population, causing irreversible changes to the epithelial membrane. The staggered nature of these events induced by serotonin slowly shifts the balance in the epithelium from reversible to irreversible. These finding have very important implications towards our ability to control epithelial regeneration and thus address pathologies of aberrant epithelial turnover, which range from degenerative disorders (e.g.; pancreatitis and thyrioditis) to proliferative disorders (e.g.; mastitis, ductal ectasia, cholangiopathies and epithelial cancers)." @default.
• W2044671396 created "2016-06-24" @default.
• W2044671396 creator A5047278434 @default.
• W2044671396 creator A5080807876 @default.
• W2044671396 date "2011-02-24" @default.
• W2044671396 modified "2023-10-06" @default.
• W2044671396 title "Multiple Cellular Responses to Serotonin Contribute to Epithelial Homeostasis" @default.
• W2044671396 cites W1975523864 @default.
• W2044671396 cites W1978500152 @default.
• W2044671396 cites W1996889745 @default.
• W2044671396 cites W1997387647 @default.
• W2044671396 cites W2000823981 @default.
• W2044671396 cites W2007640777 @default.
• W2044671396 cites W2009124930 @default.
• W2044671396 cites W2021506809 @default.
• W2044671396 cites W2026186053 @default.
• W2044671396 cites W2030079763 @default.
• W2044671396 cites W2030102531 @default.
• W2044671396 cites W2033364737 @default.
• W2044671396 cites W2040266344 @default.
• W2044671396 cites W2041110973 @default.
• W2044671396 cites W2044261540 @default.
• W2044671396 cites W2047554789 @default.
• W2044671396 cites W2053660977 @default.
• W2044671396 cites W2066630518 @default.
• W2044671396 cites W2073052871 @default.
• W2044671396 cites W2078895306 @default.
• W2044671396 cites W2084141148 @default.
• W2044671396 cites W2084961029 @default.
• W2044671396 cites W2106760703 @default.
• W2044671396 cites W2111724542 @default.
• W2044671396 cites W2118452581 @default.
• W2044671396 cites W2122902034 @default.
• W2044671396 cites W2126812800 @default.
• W2044671396 cites W2133771154 @default.
• W2044671396 cites W2134658635 @default.
• W2044671396 cites W2142018200 @default.
• W2044671396 cites W2142105477 @default.
• W2044671396 cites W2149432618 @default.
• W2044671396 cites W2153006947 @default.
• W2044671396 cites W2154333296 @default.
• W2044671396 cites W2159589487 @default.
• W2044671396 cites W2163296341 @default.
• W2044671396 cites W2171022526 @default.
• W2044671396 cites W2189490860 @default.
• W2044671396 cites W2750896950 @default.
• W2044671396 doi "https://doi.org/10.1371/journal.pone.0017028" @default.
• W2044671396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3044750" @default.
• W2044671396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21390323" @default.
• W2044671396 hasPublicationYear "2011" @default.
• W2044671396 type Work @default.
• W2044671396 sameAs 2044671396 @default.
• W2044671396 citedByCount "28" @default.
• W2044671396 countsByYear W20446713962012 @default.
• W2044671396 countsByYear W20446713962013 @default.
• W2044671396 countsByYear W20446713962014 @default.
• W2044671396 countsByYear W20446713962015 @default.
• W2044671396 countsByYear W20446713962016 @default.
• W2044671396 countsByYear W20446713962018 @default.
• W2044671396 countsByYear W20446713962019 @default.
• W2044671396 countsByYear W20446713962020 @default.
• W2044671396 countsByYear W20446713962021 @default.
• W2044671396 countsByYear W20446713962022 @default.
• W2044671396 countsByYear W20446713962023 @default.
• W2044671396 crossrefType "journal-article" @default.
• W2044671396 hasAuthorship W2044671396A5047278434 @default.
• W2044671396 hasAuthorship W2044671396A5080807876 @default.
• W2044671396 hasBestOaLocation W20446713961 @default.
• W2044671396 hasConcept C128240485 @default.
• W2044671396 hasConcept C170493617 @default.
• W2044671396 hasConcept C529295009 @default.
• W2044671396 hasConcept C54355233 @default.
• W2044671396 hasConcept C55493867 @default.
• W2044671396 hasConcept C63645605 @default.
• W2044671396 hasConcept C86803240 @default.
• W2044671396 hasConcept C95444343 @default.
• W2044671396 hasConceptScore W2044671396C128240485 @default.
• W2044671396 hasConceptScore W2044671396C170493617 @default.
• W2044671396 hasConceptScore W2044671396C529295009 @default.
• W2044671396 hasConceptScore W2044671396C54355233 @default.
• W2044671396 hasConceptScore W2044671396C55493867 @default.
• W2044671396 hasConceptScore W2044671396C63645605 @default.
• W2044671396 hasConceptScore W2044671396C86803240 @default.
• W2044671396 hasConceptScore W2044671396C95444343 @default.
• W2044671396 hasIssue "2" @default.
• W2044671396 hasLocation W20446713961 @default.
• W2044671396 hasLocation W20446713962 @default.
• W2044671396 hasLocation W20446713963 @default.
• W2044671396 hasLocation W20446713964 @default.
• W2044671396 hasOpenAccess W2044671396 @default.
• W2044671396 hasPrimaryLocation W20446713961 @default.
• W2044671396 hasRelatedWork W1641042124 @default.
• W2044671396 hasRelatedWork W1990804418 @default.
• W2044671396 hasRelatedWork W1993764875 @default.
• W2044671396 hasRelatedWork W2013243191 @default.
• W2044671396 hasRelatedWork W2082860237 @default.
• W2044671396 hasRelatedWork W2095959177 @default.
• W2044671396 hasRelatedWork W2117258802 @default.

• next