FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044674210> ?p ?o ?g. }

• W2044674210 endingPage "219" @default.
• W2044674210 startingPage "209" @default.
• W2044674210 abstract "3,4-(±)-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a ring-substituted amphetamine derivative with potent psychostimulant properties. The neuropharmacological effects of MDMA are biphasic in nature, initially causing synaptic monoamine release, primarily of serotonin (5-HT). Conversely, the long-term effects of MDMA manifest as prolonged depletions in 5-HT, and reductions in 5-HT reuptake transporter (SERT), indicative of serotonergic neurotoxicity. MDMA-induced 5-HT efflux relies upon disruption of vesicular monoamine storage, which increases cytosolic 5-HT concentrations available for release via a carrier-mediated mechanism. The vesicular monoamine transporter 2 (VMAT2) is responsible for packaging monoamine neurotransmitters into cytosolic vesicles. Thus, VMAT2 is a molecular target for a number of psychostimulant drugs, including methamphetamine and MDMA. We investigated the effects of depressed VMAT2 activity on the adverse responses to MDMA, via reversible inhibition of the VMAT2 protein with Ro4-1284. A single dose of MDMA (20 mg/kg, subcutaneous) induced significant hyperthermia in rats. Ro4-1284 (10 mg/kg, intraperitoneal) pretreatment prevented the thermogenic effects of MDMA, instead causing a transient decrease in body temperature. MDMA-treated rats exhibited marked increases in horizontal velocity and rearing behavior. In the presence of Ro4-1284, MDMA-mediated horizontal hyperlocomotion was delayed and attenuated, whereas rearing activity was abolished. Finally, Ro4-1284 prevented deficits in 5-HT content in rat cortex and striatum, and reduced depletions in striatal SERT staining, 7 days after MDMA administration. In summary, acute inhibition of VMAT2 by Ro4-1284 protected against MDMA-mediated hyperthermia, hyperactivity, and serotonergic neurotoxicity. The data suggest the involvement of VMAT2 in the thermoregulatory, behavioral, and neurotoxic effects of MDMA." @default.
• W2044674210 created "2016-06-24" @default.
• W2044674210 creator A5010399141 @default.
• W2044674210 creator A5031605226 @default.
• W2044674210 creator A5060909286 @default.
• W2044674210 creator A5060996003 @default.
• W2044674210 creator A5086522629 @default.
• W2044674210 creator A5091188351 @default.
• W2044674210 date "2014-11-04" @default.
• W2044674210 modified "2023-10-15" @default.
• W2044674210 title "Vesicular Monoamine Transporter 2 and the Acute and Long-Term Response to 3,4-(±)-Methylenedioxymethamphetamine" @default.
• W2044674210 cites W1573952878 @default.
• W2044674210 cites W1963719599 @default.
• W2044674210 cites W1966305781 @default.
• W2044674210 cites W1971746914 @default.
• W2044674210 cites W1973256378 @default.
• W2044674210 cites W1973830611 @default.
• W2044674210 cites W1977693639 @default.
• W2044674210 cites W1991141166 @default.
• W2044674210 cites W1993521516 @default.
• W2044674210 cites W1994731568 @default.
• W2044674210 cites W1996895781 @default.
• W2044674210 cites W1997460720 @default.
• W2044674210 cites W2000579895 @default.
• W2044674210 cites W2002983977 @default.
• W2044674210 cites W2009253194 @default.
• W2044674210 cites W2013836047 @default.
• W2044674210 cites W2014027156 @default.
• W2044674210 cites W2019474799 @default.
• W2044674210 cites W2031205373 @default.
• W2044674210 cites W2031305070 @default.
• W2044674210 cites W2034316728 @default.
• W2044674210 cites W2035738053 @default.
• W2044674210 cites W2037727324 @default.
• W2044674210 cites W2045198740 @default.
• W2044674210 cites W2048841731 @default.
• W2044674210 cites W2050725413 @default.
• W2044674210 cites W2064431700 @default.
• W2044674210 cites W2065850862 @default.
• W2044674210 cites W2066075695 @default.
• W2044674210 cites W2070194411 @default.
• W2044674210 cites W2073979670 @default.
• W2044674210 cites W2074163153 @default.
• W2044674210 cites W2076211114 @default.
• W2044674210 cites W2078046027 @default.
• W2044674210 cites W2085674390 @default.
• W2044674210 cites W2091280342 @default.
• W2044674210 cites W2098553992 @default.
• W2044674210 cites W2103077274 @default.
• W2044674210 cites W2109225818 @default.
• W2044674210 cites W2109698385 @default.
• W2044674210 cites W2111112265 @default.
• W2044674210 cites W2112264361 @default.
• W2044674210 cites W2118438870 @default.
• W2044674210 cites W2120611477 @default.
• W2044674210 cites W2120667212 @default.
• W2044674210 cites W2132011757 @default.
• W2044674210 cites W2138117456 @default.
• W2044674210 cites W2143308851 @default.
• W2044674210 cites W2148562084 @default.
• W2044674210 cites W2161294654 @default.
• W2044674210 doi "https://doi.org/10.1093/toxsci/kfu222" @default.
• W2044674210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274386" @default.
• W2044674210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25370842" @default.
• W2044674210 hasPublicationYear "2014" @default.
• W2044674210 type Work @default.
• W2044674210 sameAs 2044674210 @default.
• W2044674210 citedByCount "11" @default.
• W2044674210 countsByYear W20446742102016 @default.
• W2044674210 countsByYear W20446742102017 @default.
• W2044674210 countsByYear W20446742102018 @default.
• W2044674210 countsByYear W20446742102019 @default.
• W2044674210 countsByYear W20446742102020 @default.
• W2044674210 countsByYear W20446742102021 @default.
• W2044674210 countsByYear W20446742102022 @default.
• W2044674210 crossrefType "journal-article" @default.
• W2044674210 hasAuthorship W2044674210A5010399141 @default.
• W2044674210 hasAuthorship W2044674210A5031605226 @default.
• W2044674210 hasAuthorship W2044674210A5060909286 @default.
• W2044674210 hasAuthorship W2044674210A5060996003 @default.
• W2044674210 hasAuthorship W2044674210A5086522629 @default.
• W2044674210 hasAuthorship W2044674210A5091188351 @default.
• W2044674210 hasBestOaLocation W20446742101 @default.
• W2044674210 hasConcept C134018914 @default.
• W2044674210 hasConcept C170493617 @default.
• W2044674210 hasConcept C178790620 @default.
• W2044674210 hasConcept C185592680 @default.
• W2044674210 hasConcept C187714386 @default.
• W2044674210 hasConcept C2775864247 @default.
• W2044674210 hasConcept C2776291748 @default.
• W2044674210 hasConcept C2777193897 @default.
• W2044674210 hasConcept C2778406628 @default.
• W2044674210 hasConcept C2778897192 @default.
• W2044674210 hasConcept C2779491297 @default.
• W2044674210 hasConcept C2780376393 @default.
• W2044674210 hasConcept C2780876324 @default.
• W2044674210 hasConcept C29730261 @default.
• W2044674210 hasConcept C37000724 @default.

• next