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- W2044674345 abstract "G protein-coupled receptors (GPCRs) are involved in the response of eukaryotic cells to a wide variety of stimuli, traditionally mediating their effects through heterotrimeric G proteins comprised of Gα, Gβ and Gγ subunits. The fission yeast Schizosaccharomyces pombe is an established tool for GPCR research, possessing two Gα-dependent signalling cascades. A complete Gαβγ complex has been characterised for the glucose-sensing pathway, but only the Gα subunit, Gpa1p, has been identified in the pheromone-response pathway. Here, we report the use of the yeast two-hybrid system to identify a novel protein, Gnr1p, which interacts with Gpa1p. Gnr1p is predicted to contain seven WD repeats and to adopt a structure similar to typical Gβ subunits. Disruption and overexpression studies reveal that Gnr1p negatively regulates the pheromone-response pathway but is not required for signalling. Human Gβ subunits complement the loss of Gnr1p, functioning as negative regulators of Gα signalling in fission yeast." @default.
- W2044674345 created "2016-06-24" @default.
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- W2044674345 date "2006-12-01" @default.
- W2044674345 modified "2023-10-18" @default.
- W2044674345 title "Identification of Gnr1p, a negative regulator of Gα signalling in Schizosaccharomyces pombe, and its complementation by human Gβ subunits" @default.
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- W2044674345 doi "https://doi.org/10.1016/j.fgb.2006.06.005" @default.
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