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• W2044677972 abstract "Caspases play a central role in apoptosis, differentiation, and proliferation, and represent important therapeutic targets for treating cancer and inflammatory disorders. Toward the goal of developing new tools to probe caspase substrate cleavage specificity as well as to systematically interrogate caspase activation pathways, we have constructed and investigated a comprehensive panel of caspase biosensors with a split-luciferase enabled bioluminescent read out. We first interrogated the panel of caspase biosensors for substrate cleavage specificity of caspase 1–10 in widely utilized in vitro translation systems, namely, rabbit reticulocyte lysate (RRL) and wheat germ extract (WGE). Commercial RRL was found to be unsuitable for investigating caspase specificity, owing to surprising levels of endogenous caspase activity, while specificity profiles of the caspase sensors in WGE agree very well with traditional peptide probes. The full panel of biosensors was utilized for studying caspase activation and inhibition in several mammalian cytosolic extracts, clearly demonstrating that they can be utilized to directly monitor activation or inhibition of procaspase 3/7. Furthermore, the complete panel of caspase biosensors also provided new insights into caspase activation pathways wherein we surprisingly discovered the activation of procaspase 3/7 by caspase 4/5." @default.
• W2044677972 created "2016-06-24" @default.
• W2044677972 creator A5043330235 @default.
• W2044677972 creator A5069157461 @default.
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• W2044677972 date "2011-08-17" @default.
• W2044677972 modified "2023-10-03" @default.
• W2044677972 title "A Comprehensive Panel of Turn-On Caspase Biosensors for Investigating Caspase Specificity and Caspase Activation Pathways" @default.
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• W2044677972 cites W1971778847 @default.
• W2044677972 cites W1974885063 @default.
• W2044677972 cites W1975417521 @default.
• W2044677972 cites W1977219317 @default.
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• W2044677972 doi "https://doi.org/10.1002/cbic.201100372" @default.
• W2044677972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21850719" @default.
• W2044677972 hasPublicationYear "2011" @default.
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