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- W2044679849 abstract "Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated 'coupling' between the GTP-binding protein which stimulates adenylate cyclase (GNs) and the catalytic moiety of that enzyme rather than increased sensitivity to 5-hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt-Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase." @default.
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- W2044679849 date "1986-03-17" @default.
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- W2044679849 title "Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain" @default.
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- W2044679849 doi "https://doi.org/10.1016/0014-5793(86)81205-4" @default.
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