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• W2044691010 abstract "Recent studies involving HDL-raising therapeutics have greatly changed our understanding of this field. Despite effectively raising HDL-C levels, niacin remains of uncertain clinical benefit. Synthetic niacin receptor agonists are unlikely to raise HDL-C or have other beneficial effects on plasma lipids. Despite the failure in phase 3 of 2 CETP inhibitors, 2 potent CETP inhibitors that raise HDL-C levels by >100 % (and reduce LDL-C substantially) are in late stage clinical development. Infusions of recombinant HDL containing ‘wild-type’ apoA-I or apoA-I Milano, as well as autologous delipidated HDL, all demonstrated promising early results, and remain in clinical development. A small molecule that causes upregulation of endogenous apoA-I production is also in clinical development. Finally, upregulation of macrophage cholesterol efflux pathways through agonism of liver X receptors or antagonism of miR-33 remains of substantial interest. The field of HDL therapeutics is poised to transition from the ‘HDL-cholesterol hypothesis’ to the ‘HDL flux hypothesis’ in which the impact on flux from macrophage to feces is deemed to be of greater therapeutic benefit than the increase in steady-state concentrations of HDL cholesterol." @default.
• W2044691010 created "2016-06-24" @default.
• W2044691010 creator A5066952426 @default.
• W2044691010 creator A5067149045 @default.
• W2044691010 creator A5090234654 @default.
• W2044691010 date "2012-09-19" @default.
• W2044691010 modified "2023-09-27" @default.
• W2044691010 title "Targeting High Density Lipoproteins in the Prevention of Cardiovascular Disease?" @default.
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• W2044691010 cites W155704122 @default.
• W2044691010 cites W1570388980 @default.
• W2044691010 cites W1683923016 @default.
• W2044691010 cites W1805934449 @default.
• W2044691010 cites W1972597429 @default.
• W2044691010 cites W1975723271 @default.
• W2044691010 cites W1979983012 @default.
• W2044691010 cites W1983999556 @default.
• W2044691010 cites W1993601321 @default.
• W2044691010 cites W1997299383 @default.
• W2044691010 cites W1999461242 @default.
• W2044691010 cites W2003803208 @default.
• W2044691010 cites W2009580736 @default.
• W2044691010 cites W2014137262 @default.
• W2044691010 cites W2015708524 @default.
• W2044691010 cites W2020338109 @default.
• W2044691010 cites W2020647227 @default.
• W2044691010 cites W2035333536 @default.
• W2044691010 cites W2041220660 @default.
• W2044691010 cites W2042341024 @default.
• W2044691010 cites W2044822485 @default.
• W2044691010 cites W2046991199 @default.
• W2044691010 cites W2047043150 @default.
• W2044691010 cites W2048481833 @default.
• W2044691010 cites W2048760313 @default.
• W2044691010 cites W2048760408 @default.
• W2044691010 cites W2054594146 @default.
• W2044691010 cites W2058536244 @default.
• W2044691010 cites W2061250936 @default.
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• W2044691010 cites W2083507558 @default.
• W2044691010 cites W2090120461 @default.
• W2044691010 cites W2090399507 @default.
• W2044691010 cites W2090464684 @default.
• W2044691010 cites W2090600090 @default.
• W2044691010 cites W2095336654 @default.
• W2044691010 cites W2095507444 @default.
• W2044691010 cites W2101975847 @default.
• W2044691010 cites W2104650041 @default.
• W2044691010 cites W2105215768 @default.
• W2044691010 cites W2106839593 @default.
• W2044691010 cites W2108297214 @default.
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• W2044691010 cites W2119343066 @default.
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• W2044691010 cites W2123434267 @default.
• W2044691010 cites W2126666720 @default.
• W2044691010 cites W2131620609 @default.
• W2044691010 cites W2141256126 @default.
• W2044691010 cites W2142065933 @default.
• W2044691010 cites W2142246318 @default.
• W2044691010 cites W2145813488 @default.
• W2044691010 cites W2152451194 @default.
• W2044691010 cites W2153720238 @default.
• W2044691010 cites W2154213419 @default.
• W2044691010 cites W2159243445 @default.
• W2044691010 cites W2160414137 @default.
• W2044691010 cites W2162162221 @default.
• W2044691010 cites W2162674813 @default.
• W2044691010 cites W2165605025 @default.
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• W2044691010 doi "https://doi.org/10.1007/s11886-012-0317-3" @default.
• W2044691010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3517174" @default.
• W2044691010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22991041" @default.
• W2044691010 hasPublicationYear "2012" @default.
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