FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044692802> ?p ?o ?g. }

• W2044692802 endingPage "107" @default.
• W2044692802 startingPage "102" @default.
• W2044692802 abstract "S100B protein (S100B) has been described as a marker of brain injury. Various cytokines also increase in the cerebrospinal fluid (CSF) of patients with severe traumatic brain injury (TBI). Thus, we investigated early changes in the concentrations of CSF S100B and various cytokines after TBI and evaluated the relations of both S100B and cytokines to intracranial pressure (ICP) and prognosis. Twenty-three patients with severe TBI and a Glasgow Coma Scale score of 8 or less on admission were included in this study. CSF and serum samples were obtained on admission and at 6, 12, 24, 48, 72, and 96 h after injury. CSF concentrations of S100B and CSF and serum concentrations of five cytokines (IL-1beta, TNF-alpha, IL-6, IL-8, and IL-10) were measured and compared. The CSF S100B concentration was increased for 6 h after injury and decreased thereafter. The CSF concentrations of IL-6 and IL-8 peaked within 6 h after injury; other cytokines (IL-1beta, TNF-alpha, and IL-10) were elevated for 24 h after injury and gradually decreased thereafter. Peak CSF S100B concentrations correlated significantly with ICP determined at the time CSF samples were taken (r = 0.729, P < 0.0001). For the cytokines investigated, only the peak CSF IL-1beta concentration correlated significantly and positively with the peak CSF S100B concentration (r = 0.397, P < 0.005). Peak CSF concentrations of S100B (1649 +/- 415 microg/L, mean +/- SEM) and IL-1beta (16.5 +/- 3.3 pg/mL) in the 6 patients with high ICP were significantly higher than those (233 +/- 67 microg/L, 7.6 +/- 1.7 pg/mL, respectively) in the 17 patients with low ICP (P < 0.05). The CSF S100B concentration (1231 +/- 378 microg/L) in eight patients with an unfavorable outcome was significantly higher than that (267 +/- 108 microg/L) in 15 patients with a favorable outcome (P < 0.05). The CSF IL-1beta concentration (14.8 +/- 3.4 pg/mL) in eight patients with an unfavorable outcome tended to be higher than that (7.3 +/- 1.5 pg/mL) in 15 patients with a favorable outcome (P = 0.057). CSF concentrations of S100B and cytokines peak within 24 h after severe TBI and decrease gradually thereafter. CSF S100B and IL-1beta may be useful as predictors of outcome in cases of severe TBI." @default.
• W2044692802 created "2016-06-24" @default.
• W2044692802 creator A5000425806 @default.
• W2044692802 creator A5003596572 @default.
• W2044692802 creator A5009380252 @default.
• W2044692802 creator A5009848514 @default.
• W2044692802 creator A5013457309 @default.
• W2044692802 creator A5024401208 @default.
• W2044692802 creator A5039057109 @default.
• W2044692802 creator A5042321088 @default.
• W2044692802 creator A5047839525 @default.
• W2044692802 creator A5070350057 @default.
• W2044692802 creator A5075566852 @default.
• W2044692802 creator A5088019448 @default.
• W2044692802 date "2004-08-01" @default.
• W2044692802 modified "2023-10-14" @default.
• W2044692802 title "CHANGES IN CSF S100B AND CYTOKINE CONCENTRATIONS IN EARLY-PHASE SEVERE TRAUMATIC BRAIN INJURY" @default.
• W2044692802 cites W1496877897 @default.
• W2044692802 cites W1579454106 @default.
• W2044692802 cites W1603121691 @default.
• W2044692802 cites W185767050 @default.
• W2044692802 cites W1874700596 @default.
• W2044692802 cites W1948023428 @default.
• W2044692802 cites W1970885006 @default.
• W2044692802 cites W1981209372 @default.
• W2044692802 cites W1981341610 @default.
• W2044692802 cites W1999377197 @default.
• W2044692802 cites W2001573755 @default.
• W2044692802 cites W2004451348 @default.
• W2044692802 cites W2010461736 @default.
• W2044692802 cites W2012338377 @default.
• W2044692802 cites W2013700204 @default.
• W2044692802 cites W2024906564 @default.
• W2044692802 cites W2028169704 @default.
• W2044692802 cites W2033986343 @default.
• W2044692802 cites W2042735193 @default.
• W2044692802 cites W2048826724 @default.
• W2044692802 cites W2056529445 @default.
• W2044692802 cites W2057379069 @default.
• W2044692802 cites W2061750903 @default.
• W2044692802 cites W2062219794 @default.
• W2044692802 cites W2064818436 @default.
• W2044692802 cites W2070989549 @default.
• W2044692802 cites W2074992540 @default.
• W2044692802 cites W2075184975 @default.
• W2044692802 cites W2076476532 @default.
• W2044692802 cites W2087599304 @default.
• W2044692802 cites W2101509605 @default.
• W2044692802 cites W2103710494 @default.
• W2044692802 cites W2149868462 @default.
• W2044692802 cites W2327295093 @default.
• W2044692802 doi "https://doi.org/10.1097/01.shk.0000131193.80038.f1" @default.
• W2044692802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15257081" @default.
• W2044692802 hasPublicationYear "2004" @default.
• W2044692802 type Work @default.
• W2044692802 sameAs 2044692802 @default.
• W2044692802 citedByCount "213" @default.
• W2044692802 countsByYear W20446928022012 @default.
• W2044692802 countsByYear W20446928022013 @default.
• W2044692802 countsByYear W20446928022014 @default.
• W2044692802 countsByYear W20446928022015 @default.
• W2044692802 countsByYear W20446928022016 @default.
• W2044692802 countsByYear W20446928022017 @default.
• W2044692802 countsByYear W20446928022018 @default.
• W2044692802 countsByYear W20446928022019 @default.
• W2044692802 countsByYear W20446928022020 @default.
• W2044692802 countsByYear W20446928022021 @default.
• W2044692802 countsByYear W20446928022022 @default.
• W2044692802 countsByYear W20446928022023 @default.
• W2044692802 crossrefType "journal-article" @default.
• W2044692802 hasAuthorship W2044692802A5000425806 @default.
• W2044692802 hasAuthorship W2044692802A5003596572 @default.
• W2044692802 hasAuthorship W2044692802A5009380252 @default.
• W2044692802 hasAuthorship W2044692802A5009848514 @default.
• W2044692802 hasAuthorship W2044692802A5013457309 @default.
• W2044692802 hasAuthorship W2044692802A5024401208 @default.
• W2044692802 hasAuthorship W2044692802A5039057109 @default.
• W2044692802 hasAuthorship W2044692802A5042321088 @default.
• W2044692802 hasAuthorship W2044692802A5047839525 @default.
• W2044692802 hasAuthorship W2044692802A5070350057 @default.
• W2044692802 hasAuthorship W2044692802A5075566852 @default.
• W2044692802 hasAuthorship W2044692802A5088019448 @default.
• W2044692802 hasBestOaLocation W20446928021 @default.
• W2044692802 hasConcept C118552586 @default.
• W2044692802 hasConcept C11988809 @default.
• W2044692802 hasConcept C126322002 @default.
• W2044692802 hasConcept C164027704 @default.
• W2044692802 hasConcept C17624336 @default.
• W2044692802 hasConcept C17991360 @default.
• W2044692802 hasConcept C2776914184 @default.
• W2044692802 hasConcept C2778690821 @default.
• W2044692802 hasConcept C2779651940 @default.
• W2044692802 hasConcept C2780954326 @default.
• W2044692802 hasConcept C2781017439 @default.
• W2044692802 hasConcept C2781458332 @default.
• W2044692802 hasConcept C42219234 @default.
• W2044692802 hasConcept C71924100 @default.
• W2044692802 hasConcept C90924648 @default.

• next