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• W2044693459 abstract "Introduction Gallbladder cancer is an aggressive disease with dismal results of surgical treatment and a poor prognosis. However, over the last few decades selected groups have reported improved results with aggressive surgery for gallbladder cancer. Methods Review of recent world literature was done to provide an update on the current concepts of surgical treatment of this disease. Results Long-term survival is possible in early stage gallbladder carcinoma. Tis and T1a gallbladder carcinoma can be treated with simple cholecystectomy only. However, in T1b and beyond cancers, aggressive surgery (extended cholecystectomy) is important in improving the long-term prognosis. Laparoscopic cholecystectomy should not be performed where there is a high index of suspicion of malignancy due to the frequent association with factors (such as gallbladder perforation and bile spill) which may lead to implantation of cancer cells and dissemination. Surgical resection for advanced carcinoma gallbladder is recommended only if a potentially curative R0 resection is possible. Aggressive surgery with vascular and multivisceral resection has been shown to be feasible albeit with an increase in mortality and morbidity. However, the true benefit of these radical resections is yet to be realized, as the actual number of long-term survivors of advanced gallbladder carcinoma is few. Conclusions Surgery for gallbladder carcinoma, like other malignancies, has the potential to be curative only in local or regional disease. Pattern of loco-regional spread of disease dictates the surgical procedure. Radical surgery improves survival in early gallbladder carcinoma. The long-term benefit of aggressive surgery for advanced disease is unclear and may be offset by the high mortality and morbidity. J. Surg. Oncol. 2006;93:670–681. © 2006 Wiley-Liss, Inc." @default.
• W2044693459 created "2016-06-24" @default.
• W2044693459 creator A5037010915 @default.
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• W2044693459 date "2006-01-01" @default.
• W2044693459 modified "2023-10-02" @default.
• W2044693459 title "Surgical strategies in patients with gallbladder cancer: Nihilism to optimism" @default.
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• W2044693459 doi "https://doi.org/10.1002/jso.20535" @default.
• W2044693459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16724356" @default.
• W2044693459 hasPublicationYear "2006" @default.
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