Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044698935> ?p ?o ?g. }
- W2044698935 endingPage "882" @default.
- W2044698935 startingPage "874" @default.
- W2044698935 abstract "Head and neck squamous cell carcinoma (HNSCC) is a group of tumors known to be sensitive to chemotherapy and radiotherapy in patients who are treatment naive. However, when recurrences do occur, these tumors generally become resistant and objective responses to therapy at that point tend to be less effective. There has been an increasing interest in developing novel molecular-targeted agents that specifically modulate growth factor and signaling pathways that are unregulated in HNSCC tumor cells. Combinations of vascular endothelial growth factor and mammalian target of rapamycin inhibitors have been used in some types of neoplasms, but no such efforts have been made in HNSCC. In this study, we investigated the in vitro, in vivo, and clinical effects of the temsirolimus (mammalian target of rapamycin inhibitor, Tem) and bevacizumab (antivascular endothelial growth factor antibody, Bev) combination. In-vitro studies were carried out on the A431 human squamous epidermoid carcinoma cell line and in-vivo studies were carried out on A431 tumor cells implanted on female Nu/Nu*nuBR (athymic nude) mice. Also, the effectiveness of the Tem and Bev combination was tested clinically in two separate clinical cases of chemoresistant HNSCC. The in-vitro, in-vivo, and clinical results showed that this combination can be significantly effective. In conclusion, we discuss the theoretical basis of the molecular pharmacological interactions between Bev and Tem that could explain these good results. If the therapeutic index is ultimately well determined, the antitumor effect of Bev and Tem is very likely to yield fruitful results." @default.
- W2044698935 created "2016-06-24" @default.
- W2044698935 creator A5017188544 @default.
- W2044698935 creator A5030509820 @default.
- W2044698935 creator A5036094154 @default.
- W2044698935 creator A5059314345 @default.
- W2044698935 creator A5088718189 @default.
- W2044698935 date "2012-09-01" @default.
- W2044698935 modified "2023-09-25" @default.
- W2044698935 title "Indications for an alternative effective treatment of head and neck squamous cell carcinoma with temsirolimus plus bevacizumab" @default.
- W2044698935 cites W1970159404 @default.
- W2044698935 cites W1971224918 @default.
- W2044698935 cites W1975521756 @default.
- W2044698935 cites W1990594470 @default.
- W2044698935 cites W2010637272 @default.
- W2044698935 cites W2011891554 @default.
- W2044698935 cites W2023172896 @default.
- W2044698935 cites W2037068261 @default.
- W2044698935 cites W2043103956 @default.
- W2044698935 cites W2049466065 @default.
- W2044698935 cites W2055827129 @default.
- W2044698935 cites W2058531263 @default.
- W2044698935 cites W2061520589 @default.
- W2044698935 cites W2062253457 @default.
- W2044698935 cites W2076797886 @default.
- W2044698935 cites W2082303527 @default.
- W2044698935 cites W2099281944 @default.
- W2044698935 cites W2103799963 @default.
- W2044698935 cites W2115100370 @default.
- W2044698935 cites W2136871952 @default.
- W2044698935 cites W2155384808 @default.
- W2044698935 cites W2162692590 @default.
- W2044698935 cites W2247923872 @default.
- W2044698935 cites W234820190 @default.
- W2044698935 cites W2406213538 @default.
- W2044698935 cites W2971181676 @default.
- W2044698935 doi "https://doi.org/10.1097/cad.0b013e3283538c3d" @default.
- W2044698935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22510794" @default.
- W2044698935 hasPublicationYear "2012" @default.
- W2044698935 type Work @default.
- W2044698935 sameAs 2044698935 @default.
- W2044698935 citedByCount "3" @default.
- W2044698935 countsByYear W20446989352013 @default.
- W2044698935 countsByYear W20446989352014 @default.
- W2044698935 crossrefType "journal-article" @default.
- W2044698935 hasAuthorship W2044698935A5017188544 @default.
- W2044698935 hasAuthorship W2044698935A5030509820 @default.
- W2044698935 hasAuthorship W2044698935A5036094154 @default.
- W2044698935 hasAuthorship W2044698935A5059314345 @default.
- W2044698935 hasAuthorship W2044698935A5088718189 @default.
- W2044698935 hasConcept C126322002 @default.
- W2044698935 hasConcept C142724271 @default.
- W2044698935 hasConcept C143998085 @default.
- W2044698935 hasConcept C150903083 @default.
- W2044698935 hasConcept C183713625 @default.
- W2044698935 hasConcept C207001950 @default.
- W2044698935 hasConcept C2776530083 @default.
- W2044698935 hasConcept C2776694085 @default.
- W2044698935 hasConcept C2776820818 @default.
- W2044698935 hasConcept C2776833033 @default.
- W2044698935 hasConcept C2777546739 @default.
- W2044698935 hasConcept C2777802072 @default.
- W2044698935 hasConcept C2994460389 @default.
- W2044698935 hasConcept C502942594 @default.
- W2044698935 hasConcept C509974204 @default.
- W2044698935 hasConcept C55493867 @default.
- W2044698935 hasConcept C62478195 @default.
- W2044698935 hasConcept C71924100 @default.
- W2044698935 hasConcept C86554907 @default.
- W2044698935 hasConcept C86803240 @default.
- W2044698935 hasConceptScore W2044698935C126322002 @default.
- W2044698935 hasConceptScore W2044698935C142724271 @default.
- W2044698935 hasConceptScore W2044698935C143998085 @default.
- W2044698935 hasConceptScore W2044698935C150903083 @default.
- W2044698935 hasConceptScore W2044698935C183713625 @default.
- W2044698935 hasConceptScore W2044698935C207001950 @default.
- W2044698935 hasConceptScore W2044698935C2776530083 @default.
- W2044698935 hasConceptScore W2044698935C2776694085 @default.
- W2044698935 hasConceptScore W2044698935C2776820818 @default.
- W2044698935 hasConceptScore W2044698935C2776833033 @default.
- W2044698935 hasConceptScore W2044698935C2777546739 @default.
- W2044698935 hasConceptScore W2044698935C2777802072 @default.
- W2044698935 hasConceptScore W2044698935C2994460389 @default.
- W2044698935 hasConceptScore W2044698935C502942594 @default.
- W2044698935 hasConceptScore W2044698935C509974204 @default.
- W2044698935 hasConceptScore W2044698935C55493867 @default.
- W2044698935 hasConceptScore W2044698935C62478195 @default.
- W2044698935 hasConceptScore W2044698935C71924100 @default.
- W2044698935 hasConceptScore W2044698935C86554907 @default.
- W2044698935 hasConceptScore W2044698935C86803240 @default.
- W2044698935 hasIssue "8" @default.
- W2044698935 hasLocation W20446989351 @default.
- W2044698935 hasLocation W20446989352 @default.
- W2044698935 hasOpenAccess W2044698935 @default.
- W2044698935 hasPrimaryLocation W20446989351 @default.
- W2044698935 hasRelatedWork W2020319882 @default.
- W2044698935 hasRelatedWork W2043943046 @default.
- W2044698935 hasRelatedWork W2044698935 @default.