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- W2044722038 abstract "In cultured bovine adrenal chromaffin cells, NS-7 [4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy) pyrimidine hydrochloride], a newly-synthesized neuroprotective drug, inhibited nicotine-induced 22Na(+) influx via nicotinic receptors (IC(50)=15.5 microM); the suppression by NS-7 was observed in the presence of ouabain, an inhibitor of Na(+),K(+)-ATPase, and was not attenuated upon the washout of NS-7. NS-7 decreased nicotine-induced maximum influx of 22Na(+) without altering the EC(50) value of nicotine. Also, NS-7 diminished nicotine-induced 45Ca(2+) influx via nicotinic receptors and voltage-dependent Ca(2+) channels (IC(50)=14.1 microM) and catecholamine secretion (IC(50)=19.5 microM). These results suggest that NS-7 produces noncompetitive and long-lasting inhibitory effects on neuronal nicotinic receptors in adrenal chromaffin cells, and interferes with the stimulus-secretion coupling." @default.
- W2044722038 created "2016-06-24" @default.
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- W2044722038 date "2000-08-01" @default.
- W2044722038 modified "2023-10-18" @default.
- W2044722038 title "Inhibition by neuroprotective drug NS-7 of nicotine-induced 22Na+ influx, 45Ca2+ influx and catecholamine secretion in adrenal chromaffin cells" @default.
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- W2044722038 doi "https://doi.org/10.1016/s0006-8993(00)02492-6" @default.
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