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- W2044729529 abstract "An atomic-level insight into the functioning of articular cartilage would be useful to develop prevention strategies and therapies for joint diseases such as osteoarthritis. However, the composition and structure of cartilage and their relationship to its unique mechanical properties are quite complex and pose tremendous challenges to most biophysical techniques. In this study, we present an investigation of the structure and dynamics of polymeric molecules of articular cartilage using time-resolved solid-state NMR spectroscopy during dehydration. Full-thickness cartilage explants were used in magic-angle spinning experiments to monitor the structural changes of rigid and mobile carbons. Our results reveal that the dehydration reduced the mobility of collagen amino acid residues and carbon sugar ring structures in glycosaminoglycans but had no effect on the trans-Xaa-Pro conformation. Equally interestingly, our results demonstrate that the dehydration effects are reversible, and the molecular structure and mobility are restored upon rehydration." @default.
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- W2044729529 date "2011-08-02" @default.
- W2044729529 modified "2023-09-23" @default.
- W2044729529 title "Solid-State NMR Spectroscopy Provides Atomic-Level Insights Into the Dehydration of Cartilage" @default.
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- W2044729529 doi "https://doi.org/10.1021/jp205663z" @default.
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