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- W2044738373 abstract "Introduction: Zinc deficiency in breast-fed infants is a rare disorder, unfrequently reported, caused by a low level of zinc in mother’s milk. Premature infants are more vulnerable to develop zinc deficiency than full-term infants because they have insufficient body stores of zinc and a reduced absorption of zinc from the gut. The clinical features resembles those of hereditary acrodermatitis enteropathica (AE). In acquired zinc deficiencies, the disorder is transient and the patients respond well to oral zinc supplements. Methods: Clinical case: A 4 months-old exclusively breast-fed premature infant presented with persistent diarrhea, vomiting and eczematoid skin lesions, with acral and periorificial dermatitis resembling AE. The symptoms began at 2 months of age. The gestational age was 27 weeks and the birth weight 1150 g. Results: Results of laboratory investigations revealed lowered zinc levels in the infant’s serum (3 mumol/l) and in her mother’s milk (8 mumol/l), with normal level of zinc in the mother’s serum (17 mumol/l). A rapid healing occurred after oral zinc supplementation (zinc sulfate 2 mg/kg), with complete remission of the symptoms at the end of one month. By age of 10 months the infant was well and no longer required zinc supplements. There was no recurrence of the lesions one year after the treatment was completely stopped. Conclusion: Symptomatic zinc deficiency in breast-fed pre-term infants is a rare, but important disorder, with symptoms resembling hereditary AE. Several pathophysiological mechanisms are involved in acquired zinc deficiency. Reports of similar cases suggest that breast milk does not meet the nutritional zinc requirements in these patients. Lower zinc levels in mother milk could be produced by a defect in transfer of zinc from maternal serum to breast milk or because of defective mammary secretion. This may lead to severe symptomatic zinc deficiency in premature infants, that may have insufficient body stores of zinc, requiring treatment with oral zinc supplements. When nursing ends and the diet is diversified, the infant no longer requires the supplements. Intestinal biopsy to rule out hereditary AE is required when the symptoms persist or relapse after withdrawal of the treatment." @default.
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- W2044738373 date "2004-06-01" @default.
- W2044738373 modified "2023-09-26" @default.
- W2044738373 title "P0947 ZINC DEFICIENCY AND TRANSITORY ACRODERMATITIS ENTEROPATHICA IN PRETERM BREAST-FED INFANT" @default.
- W2044738373 doi "https://doi.org/10.1097/00005176-200406001-01071" @default.
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