FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044741008> ?p ?o ?g. }

• W2044741008 endingPage "505" @default.
• W2044741008 startingPage "497" @default.
• W2044741008 abstract "PH (pulmonary hypertension) often complicates the disease course of patients with COPD (chronic obstructive pulmonary disease) and is an indication of a worse prognosis. In the present study, we assessed whether pravastatin administration was effective in improving PH and exercise capacity in COPD patients with PH, and whether the pulmonary protection was mediated by inhibiting ET-1 (endothelin-1) production. In a double-blind parallel design, 53 COPD patients with PH were randomly assigned to receive either placebo or pravastatin (40 mg/day) over a period of 6 months at a medical centre. Baseline characteristics were similar in both groups. The exercise time remained stable throughout the study in the placebo group. After 6 months, the exercise time significantly increased 52% from 660+/-352 to 1006+/-316 s (P<0.0001) in pravastatin-treated patients. With pravastatin, echocardiographically derived systolic PAP (pulmonary artery pressure) decreased significantly from 47+/-8 to 40+/-6 mmHg. There was significant improvement in the Borg dyspnoea score after administering pravastatin. Despite unchanged plasma ET-1 levels throughout the study, urinary excretion of the peptide was decreased and significantly correlated with an improvement in exercise time in pravastatin-treated patients (r=-0.47, P=0.01). In conclusion, pravastatin significantly improved exercise tolerance, and decreased PH and dyspnoea during exercise in COPD patients with PH, probably by inhibiting ET-1 synthesis." @default.
• W2044741008 created "2016-06-24" @default.
• W2044741008 creator A5001353044 @default.
• W2044741008 creator A5002352001 @default.
• W2044741008 creator A5071538760 @default.
• W2044741008 creator A5083180396 @default.
• W2044741008 date "2009-02-12" @default.
• W2044741008 modified "2023-10-01" @default.
• W2044741008 title "Effects of pravastatin on functional capacity in patients with chronic obstructive pulmonary disease and pulmonary hypertension" @default.
• W2044741008 cites W137057924 @default.
• W2044741008 cites W1813207029 @default.
• W2044741008 cites W1946263363 @default.
• W2044741008 cites W1973691307 @default.
• W2044741008 cites W1975914758 @default.
• W2044741008 cites W1994073265 @default.
• W2044741008 cites W2010245527 @default.
• W2044741008 cites W2012065393 @default.
• W2044741008 cites W2013211910 @default.
• W2044741008 cites W2016965317 @default.
• W2044741008 cites W2020706943 @default.
• W2044741008 cites W2021867486 @default.
• W2044741008 cites W2027415701 @default.
• W2044741008 cites W2035195166 @default.
• W2044741008 cites W2036061790 @default.
• W2044741008 cites W2044803705 @default.
• W2044741008 cites W2045616259 @default.
• W2044741008 cites W2048179019 @default.
• W2044741008 cites W2066519927 @default.
• W2044741008 cites W2066857860 @default.
• W2044741008 cites W2074757812 @default.
• W2044741008 cites W2074971666 @default.
• W2044741008 cites W2076644187 @default.
• W2044741008 cites W2082747640 @default.
• W2044741008 cites W2091379117 @default.
• W2044741008 cites W2095960585 @default.
• W2044741008 cites W2097875884 @default.
• W2044741008 cites W2123337869 @default.
• W2044741008 cites W2132827941 @default.
• W2044741008 cites W2135211593 @default.
• W2044741008 cites W2135819121 @default.
• W2044741008 cites W2144818392 @default.
• W2044741008 cites W2167725249 @default.
• W2044741008 cites W2233163131 @default.
• W2044741008 cites W2331798828 @default.
• W2044741008 cites W2614242365 @default.
• W2044741008 doi "https://doi.org/10.1042/cs20080241" @default.
• W2044741008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18831711" @default.
• W2044741008 hasPublicationYear "2009" @default.
• W2044741008 type Work @default.
• W2044741008 sameAs 2044741008 @default.
• W2044741008 citedByCount "89" @default.
• W2044741008 countsByYear W20447410082012 @default.
• W2044741008 countsByYear W20447410082013 @default.
• W2044741008 countsByYear W20447410082014 @default.
• W2044741008 countsByYear W20447410082015 @default.
• W2044741008 countsByYear W20447410082016 @default.
• W2044741008 countsByYear W20447410082017 @default.
• W2044741008 countsByYear W20447410082018 @default.
• W2044741008 countsByYear W20447410082019 @default.
• W2044741008 countsByYear W20447410082020 @default.
• W2044741008 countsByYear W20447410082021 @default.
• W2044741008 countsByYear W20447410082022 @default.
• W2044741008 countsByYear W20447410082023 @default.
• W2044741008 crossrefType "journal-article" @default.
• W2044741008 hasAuthorship W2044741008A5001353044 @default.
• W2044741008 hasAuthorship W2044741008A5002352001 @default.
• W2044741008 hasAuthorship W2044741008A5071538760 @default.
• W2044741008 hasAuthorship W2044741008A5083180396 @default.
• W2044741008 hasConcept C10146269 @default.
• W2044741008 hasConcept C126322002 @default.
• W2044741008 hasConcept C142724271 @default.
• W2044741008 hasConcept C164705383 @default.
• W2044741008 hasConcept C204787440 @default.
• W2044741008 hasConcept C27081682 @default.
• W2044741008 hasConcept C2776780178 @default.
• W2044741008 hasConcept C2778163477 @default.
• W2044741008 hasConcept C2779519902 @default.
• W2044741008 hasConcept C2780930700 @default.
• W2044741008 hasConcept C2780940725 @default.
• W2044741008 hasConcept C71924100 @default.
• W2044741008 hasConcept C90924648 @default.
• W2044741008 hasConceptScore W2044741008C10146269 @default.
• W2044741008 hasConceptScore W2044741008C126322002 @default.
• W2044741008 hasConceptScore W2044741008C142724271 @default.
• W2044741008 hasConceptScore W2044741008C164705383 @default.
• W2044741008 hasConceptScore W2044741008C204787440 @default.
• W2044741008 hasConceptScore W2044741008C27081682 @default.
• W2044741008 hasConceptScore W2044741008C2776780178 @default.
• W2044741008 hasConceptScore W2044741008C2778163477 @default.
• W2044741008 hasConceptScore W2044741008C2779519902 @default.
• W2044741008 hasConceptScore W2044741008C2780930700 @default.
• W2044741008 hasConceptScore W2044741008C2780940725 @default.
• W2044741008 hasConceptScore W2044741008C71924100 @default.
• W2044741008 hasConceptScore W2044741008C90924648 @default.
• W2044741008 hasIssue "6" @default.
• W2044741008 hasLocation W20447410081 @default.
• W2044741008 hasLocation W20447410082 @default.
• W2044741008 hasOpenAccess W2044741008 @default.

• next