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• W2044749569 abstract "To assess alterations in the regional perfusion and oxygenation of the calf muscles in individuals with diabetes.Age-matched individuals with (n = 5) and without diabetes (n = 6) were investigated. Skeletal muscle perfusion, oxygen extraction fraction, and oxygen consumption rate were measured by newly developed noncontrast magnetic resonance imaging (MRI) techniques. The subjects lay supine on the MRI table with their foot firmly strapped to a custom-built isometric exercise device. The measurements were performed at rest and during an isometric plantar flexion muscle contraction.Individuals without diabetes had up to a 10-fold increase in muscle perfusion, 25% elevation in muscle oxygen extraction fraction, and a 12-fold increase in oxygen consumption rate in the calf during the plantar flexion isometric contraction. In patients with diabetes, the increases in these parameters were only up to sixfold, 2%, and sixfold, respectively. Exercise oxygen consumption rate was inversely associated with blood HbA1c levels (r(2) = .91).This is the first study to quantify regional skeletal muscle oxygenation in patients with diabetes using noncontrast MRI and warrants additional study. Attenuation of perfusion and oxygenation during exercise may have implications for understanding diabetic complications in the lower extremities." @default.
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• W2044749569 date "2014-02-01" @default.
• W2044749569 modified "2023-10-15" @default.
• W2044749569 title "A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure" @default.
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• W2044749569 doi "https://doi.org/10.1016/j.jvs.2013.07.115" @default.
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