Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044751918> ?p ?o ?g. }
- W2044751918 endingPage "593" @default.
- W2044751918 startingPage "586" @default.
- W2044751918 abstract "Oxidized analogs of cholesterol (oxysterols) are produced through both enzymatic and non-enzymatic pathways and have been shown to perturb membrane properties in vitro and in vivo. In the present study, the membrane behavior of two naturally occurring oxysterols, 25-hydroxycholesterol and 7-ketocholesterol, was examined in two model systems. The presence of an additional oxygen moiety was found to alter membrane properties compared to native cholesterol and to each other in lipid monolayers, composed of either pure sterol or sterol–glycerophospholipid and sterol–sphingomyelin binary films, as well as in mixed multilamellar vesicles. The ability of oxysterols to condense phosphatidylcholine and sphingomyelin films, their capacity to cause changes in in-plane elasticity moduli, and their propensity to form detergent-resistant membrane domains were all found to be dependant on the location of the oxygen functionality in the oxysterol, the chemical nature of the phospholipid in the model systems, and the oxysterol/phospholipid ratio in the membrane. The findings described in this study with respect to their biophysical/biophysiological implications provide additional insight into the activity of cytotoxic oxysterols in model membranes." @default.
- W2044751918 created "2016-06-24" @default.
- W2044751918 creator A5000574010 @default.
- W2044751918 creator A5006940147 @default.
- W2044751918 creator A5073226659 @default.
- W2044751918 date "2010-06-01" @default.
- W2044751918 modified "2023-10-17" @default.
- W2044751918 title "Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes" @default.
- W2044751918 cites W1509346516 @default.
- W2044751918 cites W157189559 @default.
- W2044751918 cites W1914926542 @default.
- W2044751918 cites W1970314190 @default.
- W2044751918 cites W1971730469 @default.
- W2044751918 cites W1974282614 @default.
- W2044751918 cites W1974974777 @default.
- W2044751918 cites W1975325447 @default.
- W2044751918 cites W1976295444 @default.
- W2044751918 cites W1980400254 @default.
- W2044751918 cites W1982530453 @default.
- W2044751918 cites W1985009426 @default.
- W2044751918 cites W1989928327 @default.
- W2044751918 cites W1990632046 @default.
- W2044751918 cites W1993485272 @default.
- W2044751918 cites W1996380871 @default.
- W2044751918 cites W2001812923 @default.
- W2044751918 cites W2004767898 @default.
- W2044751918 cites W2016441481 @default.
- W2044751918 cites W2017506227 @default.
- W2044751918 cites W2017965509 @default.
- W2044751918 cites W2023125175 @default.
- W2044751918 cites W2026393575 @default.
- W2044751918 cites W2027183666 @default.
- W2044751918 cites W2029872997 @default.
- W2044751918 cites W2030505286 @default.
- W2044751918 cites W2031811455 @default.
- W2044751918 cites W2041155688 @default.
- W2044751918 cites W2041512421 @default.
- W2044751918 cites W2041599285 @default.
- W2044751918 cites W2046365552 @default.
- W2044751918 cites W2048958063 @default.
- W2044751918 cites W2049334533 @default.
- W2044751918 cites W2056993355 @default.
- W2044751918 cites W2060073882 @default.
- W2044751918 cites W2065886456 @default.
- W2044751918 cites W2079080809 @default.
- W2044751918 cites W2080885358 @default.
- W2044751918 cites W2083063732 @default.
- W2044751918 cites W2083957918 @default.
- W2044751918 cites W2084320337 @default.
- W2044751918 cites W2089670256 @default.
- W2044751918 cites W2092285520 @default.
- W2044751918 cites W2092880628 @default.
- W2044751918 cites W2094061346 @default.
- W2044751918 cites W2105108972 @default.
- W2044751918 cites W2110852753 @default.
- W2044751918 cites W2113574245 @default.
- W2044751918 cites W2114099824 @default.
- W2044751918 cites W2120150168 @default.
- W2044751918 cites W2121936687 @default.
- W2044751918 cites W2148397172 @default.
- W2044751918 cites W2152430290 @default.
- W2044751918 cites W2163407551 @default.
- W2044751918 cites W2165148465 @default.
- W2044751918 cites W2169397893 @default.
- W2044751918 cites W2188056684 @default.
- W2044751918 cites W2402730912 @default.
- W2044751918 cites W2402894416 @default.
- W2044751918 doi "https://doi.org/10.1016/j.chemphyslip.2010.05.001" @default.
- W2044751918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20471966" @default.
- W2044751918 hasPublicationYear "2010" @default.
- W2044751918 type Work @default.
- W2044751918 sameAs 2044751918 @default.
- W2044751918 citedByCount "31" @default.
- W2044751918 countsByYear W20447519182012 @default.
- W2044751918 countsByYear W20447519182013 @default.
- W2044751918 countsByYear W20447519182014 @default.
- W2044751918 countsByYear W20447519182015 @default.
- W2044751918 countsByYear W20447519182016 @default.
- W2044751918 countsByYear W20447519182017 @default.
- W2044751918 countsByYear W20447519182018 @default.
- W2044751918 countsByYear W20447519182019 @default.
- W2044751918 countsByYear W20447519182020 @default.
- W2044751918 countsByYear W20447519182021 @default.
- W2044751918 countsByYear W20447519182022 @default.
- W2044751918 countsByYear W20447519182023 @default.
- W2044751918 crossrefType "journal-article" @default.
- W2044751918 hasAuthorship W2044751918A5000574010 @default.
- W2044751918 hasAuthorship W2044751918A5006940147 @default.
- W2044751918 hasAuthorship W2044751918A5073226659 @default.
- W2044751918 hasConcept C12554922 @default.
- W2044751918 hasConcept C130316041 @default.
- W2044751918 hasConcept C185154212 @default.
- W2044751918 hasConcept C185592680 @default.
- W2044751918 hasConcept C2776330855 @default.
- W2044751918 hasConcept C2776952329 @default.
- W2044751918 hasConcept C2778111914 @default.
- W2044751918 hasConcept C2778163477 @default.
- W2044751918 hasConcept C2778718757 @default.