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- W2044752103 abstract "Our purpose was to investigate the binding characteristics of central a-adrenoceptors during the early stages of the development of hypertension in rats on high and low salt (NaCI) intake. We measured ar([3H]prazosin) and a2-([3H]rauwolscine) binding in membranes of the hypothalamus 'and*medulla oblongata of six groups of young Wistar-Kyoto (WKY) rats, spontaneously hypertensive rats (SHR) and subtotally nephrectomized WKY (SN) rats with mean arterial blood pressure (MAP) ranging from normotensive to hypertensive levels-after 1 week of salt restriction or loading. In the hypothalamus the SN-high salt rats and both SHR groups had elevated ^-number but there was no change in a2-number. Moreover, MAP was positively correlated with mean hypothalamic arnumber in the six groups. In the medulla oblongata ^-number was unaffected. However, high salt diet influenced medullary a2-binding in the opposite manner in WKY rats versus SN rats and SHR. In these latter groups the affinity was increased and the number decreased in response to high salt intake. Furthermore, a positive correlation between MAP and mean a-i:a2 ratio existed in both the hypothalamus and the medulla of the six groups. The data suggest that hypothalamic arbinding capacity was increased in SHR due principally to a genetic condition which is mimicked by salt loading in the SN rats. Medullary a2-adrenoceptors of WKY, which remained normotensive despite salt loading, responded differently to high salt intake than those of the SN and SHR, whose blood pressure rose significantly. In view of the involvement of medullary a2- adrenoceptors in baroreflex activity, these findings suggest that WKY may maintain sympatho-inhibition by up-regulating medullary a2-fc>inding capacity while in SN and SHR the opposite tendency may be related to central sympathetic overdrive, characteristic of these types of hypertension." @default.
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- W2044752103 date "1986-12-01" @default.
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- W2044752103 title "Central Alpha-Adrenoceptors During the Development of Hypertension in Rats on High and Low Salt Intake" @default.
- W2044752103 doi "https://doi.org/10.1097/00004872-198612000-00006" @default.
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