FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044755839> ?p ?o ?g. }

• W2044755839 endingPage "110" @default.
• W2044755839 startingPage "99" @default.
• W2044755839 abstract "The interaction of bovine α-lactalbumin (BLA) with negatively charged phospholipid bilayers was studied by NMR monitored 1H exchange to characterize the conformational transition that enables a water-soluble protein to associate with and partially insert into a membrane. BLA was allowed to exchange in deuterated buffer in the absence (reference) and the presence (membrane-bound) of acidic liposomes at pH 4.5, experimental conditions that allow efficient protein–membrane interaction. After adjusting the pH to 6.0, to dissociate the protein from the membrane, reference and membrane-released samples of BLA were analysed by (F1) band-selective homonuclear decoupled total correlation spectroscopy in the αH–NH region. The overall exchange behaviour of the membrane-bound state is molten globule-like, suggesting an overall destabilization of the polypeptide. Nevertheless, the backbone amide protons of residues R10, L12, C77, K94, K98, V99 and W104 show significant protection against solvent exchange in the membrane-bound protein. We propose a mechanism for the association of BLA with negatively charged membranes that includes initial protonation of acidic side-chains at the membrane interface, and formation of an interacting site with the membrane which involves helixes A and C. In the next step these helices would slide away from each other, adopting a parallel orientation to the membrane, and would rotate to maximize the interaction between their hydrophobic residues and the lipid bilayer." @default.
• W2044755839 created "2016-06-24" @default.
• W2044755839 creator A5002837759 @default.
• W2044755839 creator A5057805699 @default.
• W2044755839 creator A5067586951 @default.
• W2044755839 creator A5073885248 @default.
• W2044755839 date "2002-08-01" @default.
• W2044755839 modified "2023-10-10" @default.
• W2044755839 title "The Membrane-bound Conformation of α-Lactalbumin Studied by NMR-monitored 1H Exchange" @default.
• W2044755839 cites W1508039024 @default.
• W2044755839 cites W1965435932 @default.
• W2044755839 cites W1970934250 @default.
• W2044755839 cites W1981059006 @default.
• W2044755839 cites W1990047565 @default.
• W2044755839 cites W1990407294 @default.
• W2044755839 cites W2001111622 @default.
• W2044755839 cites W2003673431 @default.
• W2044755839 cites W2007560959 @default.
• W2044755839 cites W2008585649 @default.
• W2044755839 cites W2025874401 @default.
• W2044755839 cites W2030011267 @default.
• W2044755839 cites W2032545721 @default.
• W2044755839 cites W2033444170 @default.
• W2044755839 cites W2034588388 @default.
• W2044755839 cites W2036645831 @default.
• W2044755839 cites W2047187986 @default.
• W2044755839 cites W2055205074 @default.
• W2044755839 cites W2069899635 @default.
• W2044755839 cites W2071197656 @default.
• W2044755839 cites W2071351912 @default.
• W2044755839 cites W2076397699 @default.
• W2044755839 cites W2076755375 @default.
• W2044755839 cites W2078802956 @default.
• W2044755839 cites W2087095360 @default.
• W2044755839 cites W2089764687 @default.
• W2044755839 cites W2114150548 @default.
• W2044755839 cites W2114320763 @default.
• W2044755839 cites W2126469537 @default.
• W2044755839 cites W2131653836 @default.
• W2044755839 cites W2141260882 @default.
• W2044755839 cites W2155147384 @default.
• W2044755839 cites W2156339131 @default.
• W2044755839 doi "https://doi.org/10.1016/s0022-2836(02)00565-x" @default.
• W2044755839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12139936" @default.
• W2044755839 hasPublicationYear "2002" @default.
• W2044755839 type Work @default.
• W2044755839 sameAs 2044755839 @default.
• W2044755839 citedByCount "73" @default.
• W2044755839 countsByYear W20447558392012 @default.
• W2044755839 countsByYear W20447558392013 @default.
• W2044755839 countsByYear W20447558392014 @default.
• W2044755839 countsByYear W20447558392016 @default.
• W2044755839 countsByYear W20447558392017 @default.
• W2044755839 countsByYear W20447558392018 @default.
• W2044755839 countsByYear W20447558392019 @default.
• W2044755839 countsByYear W20447558392020 @default.
• W2044755839 countsByYear W20447558392021 @default.
• W2044755839 countsByYear W20447558392022 @default.
• W2044755839 countsByYear W20447558392023 @default.
• W2044755839 crossrefType "journal-article" @default.
• W2044755839 hasAuthorship W2044755839A5002837759 @default.
• W2044755839 hasAuthorship W2044755839A5057805699 @default.
• W2044755839 hasAuthorship W2044755839A5067586951 @default.
• W2044755839 hasAuthorship W2044755839A5073885248 @default.
• W2044755839 hasConcept C12554922 @default.
• W2044755839 hasConcept C144647389 @default.
• W2044755839 hasConcept C162356407 @default.
• W2044755839 hasConcept C167569220 @default.
• W2044755839 hasConcept C185154212 @default.
• W2044755839 hasConcept C185592680 @default.
• W2044755839 hasConcept C192157962 @default.
• W2044755839 hasConcept C2778918659 @default.
• W2044755839 hasConcept C39944091 @default.
• W2044755839 hasConcept C41625074 @default.
• W2044755839 hasConcept C43617362 @default.
• W2044755839 hasConcept C55493867 @default.
• W2044755839 hasConcept C66974803 @default.
• W2044755839 hasConcept C68863886 @default.
• W2044755839 hasConcept C71240020 @default.
• W2044755839 hasConcept C8010536 @default.
• W2044755839 hasConcept C86803240 @default.
• W2044755839 hasConceptScore W2044755839C12554922 @default.
• W2044755839 hasConceptScore W2044755839C144647389 @default.
• W2044755839 hasConceptScore W2044755839C162356407 @default.
• W2044755839 hasConceptScore W2044755839C167569220 @default.
• W2044755839 hasConceptScore W2044755839C185154212 @default.
• W2044755839 hasConceptScore W2044755839C185592680 @default.
• W2044755839 hasConceptScore W2044755839C192157962 @default.
• W2044755839 hasConceptScore W2044755839C2778918659 @default.
• W2044755839 hasConceptScore W2044755839C39944091 @default.
• W2044755839 hasConceptScore W2044755839C41625074 @default.
• W2044755839 hasConceptScore W2044755839C43617362 @default.
• W2044755839 hasConceptScore W2044755839C55493867 @default.
• W2044755839 hasConceptScore W2044755839C66974803 @default.
• W2044755839 hasConceptScore W2044755839C68863886 @default.
• W2044755839 hasConceptScore W2044755839C71240020 @default.
• W2044755839 hasConceptScore W2044755839C8010536 @default.
• W2044755839 hasConceptScore W2044755839C86803240 @default.

• next