FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044762564> ?p ?o ?g. }

• W2044762564 endingPage "1557" @default.
• W2044762564 startingPage "1548" @default.
• W2044762564 abstract "Phenotypic switching of smooth muscle cells (SMCs) plays a key role in vascular proliferative diseases. We previously showed that Krüppel-like factor 4 (Klf4) suppressed SMC differentiation markers in cultured SMCs. Here, we derive mice deficient for Klf4 by conditional gene ablation and analyze their vascular phenotype following carotid injury. Klf4 expression was rapidly induced in SMCs of control mice after vascular injury but not in Klf4 -deficient mice. Injury-induced repression of SMC differentiation markers was transiently delayed in Klf4 -deficient mice. Klf4 mutant mice exhibited enhanced neointimal formation in response to vascular injury caused by increased cellular proliferation in the media but not an altered apoptotic rate. Consistent with these findings, cultured SMCs overexpressing Klf4 showed reduced cellular proliferation, in part, through the induction of the cell cycle inhibitor, p21 WAF1/Cip1 via increased binding of Klf4 and p53 to the p21 WAF1/Cip1 promoter/enhancer. In vivo chromatin immunoprecipitation assays also showed increased Klf4 binding to the promoter/enhancer regions of the p21 WAF1/Cip1 gene and SMC differentiation marker genes following vascular injury. Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury." @default.
• W2044762564 created "2016-06-24" @default.
• W2044762564 creator A5006497339 @default.
• W2044762564 creator A5012746992 @default.
• W2044762564 creator A5073520886 @default.
• W2044762564 date "2008-06-20" @default.
• W2044762564 modified "2023-10-15" @default.
• W2044762564 title "Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury" @default.
• W2044762564 cites W1513329088 @default.
• W2044762564 cites W1995889915 @default.
• W2044762564 cites W1997447547 @default.
• W2044762564 cites W1999182913 @default.
• W2044762564 cites W2001025517 @default.
• W2044762564 cites W2008798787 @default.
• W2044762564 cites W2015519364 @default.
• W2044762564 cites W2025476423 @default.
• W2044762564 cites W2026299035 @default.
• W2044762564 cites W2028405970 @default.
• W2044762564 cites W2030036124 @default.
• W2044762564 cites W2039611809 @default.
• W2044762564 cites W2039971229 @default.
• W2044762564 cites W2045049295 @default.
• W2044762564 cites W2066060929 @default.
• W2044762564 cites W2067561562 @default.
• W2044762564 cites W2070114011 @default.
• W2044762564 cites W2089895401 @default.
• W2044762564 cites W2106896953 @default.
• W2044762564 cites W2115950020 @default.
• W2044762564 cites W2121822802 @default.
• W2044762564 cites W2130489491 @default.
• W2044762564 cites W2134918940 @default.
• W2044762564 cites W2154389382 @default.
• W2044762564 cites W2156935469 @default.
• W2044762564 doi "https://doi.org/10.1161/circresaha.108.176974" @default.
• W2044762564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2633447" @default.
• W2044762564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18483411" @default.
• W2044762564 hasPublicationYear "2008" @default.
• W2044762564 type Work @default.
• W2044762564 sameAs 2044762564 @default.
• W2044762564 citedByCount "207" @default.
• W2044762564 countsByYear W20447625642012 @default.
• W2044762564 countsByYear W20447625642013 @default.
• W2044762564 countsByYear W20447625642014 @default.
• W2044762564 countsByYear W20447625642015 @default.
• W2044762564 countsByYear W20447625642016 @default.
• W2044762564 countsByYear W20447625642017 @default.
• W2044762564 countsByYear W20447625642018 @default.
• W2044762564 countsByYear W20447625642019 @default.
• W2044762564 countsByYear W20447625642020 @default.
• W2044762564 countsByYear W20447625642021 @default.
• W2044762564 countsByYear W20447625642022 @default.
• W2044762564 countsByYear W20447625642023 @default.
• W2044762564 crossrefType "journal-article" @default.
• W2044762564 hasAuthorship W2044762564A5006497339 @default.
• W2044762564 hasAuthorship W2044762564A5012746992 @default.
• W2044762564 hasAuthorship W2044762564A5073520886 @default.
• W2044762564 hasBestOaLocation W20447625641 @default.
• W2044762564 hasConcept C101762097 @default.
• W2044762564 hasConcept C104317684 @default.
• W2044762564 hasConcept C126322002 @default.
• W2044762564 hasConcept C127561419 @default.
• W2044762564 hasConcept C127716648 @default.
• W2044762564 hasConcept C134018914 @default.
• W2044762564 hasConcept C134320426 @default.
• W2044762564 hasConcept C148738053 @default.
• W2044762564 hasConcept C150194340 @default.
• W2044762564 hasConcept C153911025 @default.
• W2044762564 hasConcept C164659718 @default.
• W2044762564 hasConcept C2777339539 @default.
• W2044762564 hasConcept C2777933648 @default.
• W2044762564 hasConcept C2778265714 @default.
• W2044762564 hasConcept C2778283817 @default.
• W2044762564 hasConcept C2778583881 @default.
• W2044762564 hasConcept C2779395532 @default.
• W2044762564 hasConcept C2781011225 @default.
• W2044762564 hasConcept C2992686903 @default.
• W2044762564 hasConcept C502942594 @default.
• W2044762564 hasConcept C54355233 @default.
• W2044762564 hasConcept C69053785 @default.
• W2044762564 hasConcept C71924100 @default.
• W2044762564 hasConcept C86339819 @default.
• W2044762564 hasConcept C86803240 @default.
• W2044762564 hasConcept C95444343 @default.
• W2044762564 hasConceptScore W2044762564C101762097 @default.
• W2044762564 hasConceptScore W2044762564C104317684 @default.
• W2044762564 hasConceptScore W2044762564C126322002 @default.
• W2044762564 hasConceptScore W2044762564C127561419 @default.
• W2044762564 hasConceptScore W2044762564C127716648 @default.
• W2044762564 hasConceptScore W2044762564C134018914 @default.
• W2044762564 hasConceptScore W2044762564C134320426 @default.
• W2044762564 hasConceptScore W2044762564C148738053 @default.
• W2044762564 hasConceptScore W2044762564C150194340 @default.
• W2044762564 hasConceptScore W2044762564C153911025 @default.
• W2044762564 hasConceptScore W2044762564C164659718 @default.
• W2044762564 hasConceptScore W2044762564C2777339539 @default.
• W2044762564 hasConceptScore W2044762564C2777933648 @default.
• W2044762564 hasConceptScore W2044762564C2778265714 @default.
• W2044762564 hasConceptScore W2044762564C2778283817 @default.

• next