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- W2044762607 abstract "Background: Sentinel node biopsies (SNBs) have been clinically applied in melanoma and breast cancer for limited lymphadenectomy. However, the use of SNB remains controversial in gastric cancer due to unsatisfactory sensitivity and variability. This meta-analysis was performed to determine the sensitivity of SNB in gastric cancer and to identify factors that improve its sensitivity. Methods Feasibility studies on SNB in gastric cancer were searched for from 2001 to 2009 in Pubmed, Cochrane, and Embase. Forty-six reports, which included 2,684 patients, were found. Estimated sensitivities, detection rates, and negative (NPV), and positive predictive values (PPV) were calculated using a random effects model. Inter-study heterogeneity, meta-regression, and subgroup analysis for sensitivity was performed. Results The estimated sensitivity, detection rate, NPV, and PPV were 87.8%, 97.5%, 91.8%, and 38.0%, respectively, with significant inter-study heterogeneity (P < 0.0001). However, no significant contributor to heterogeneity was identified. By subgroup analysis, sensitivity was found to depend significantly on the number of SNs harvested. Conclusions SNB in gastric cancer is probably not clinically applicable for limited lymphadenectomy due its unsatisfactory sensitivity and heterogeneity between practicing surgeons. To improve sensitivity, more than four SNs should be harvested, and a tumor specific SNB method should be developed. J. Surg. Oncol. 2011; 104:578–584. © 2011 Wiley Periodicals, Inc." @default.
- W2044762607 created "2016-06-24" @default.
- W2044762607 creator A5035551203 @default.
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- W2044762607 creator A5076132049 @default.
- W2044762607 creator A5079140720 @default.
- W2044762607 date "2011-06-21" @default.
- W2044762607 modified "2023-10-18" @default.
- W2044762607 title "Is the sentinel node biopsy clinically applicable for limited lymphadenectomy and modified gastric resection in gastric cancer? A meta-analysis of feasibility studies" @default.
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- W2044762607 doi "https://doi.org/10.1002/jso.21995" @default.
- W2044762607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21695700" @default.
- W2044762607 hasPublicationYear "2011" @default.
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