FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044763721> ?p ?o ?g. }

• W2044763721 endingPage "134" @default.
• W2044763721 startingPage "127" @default.
• W2044763721 abstract "Methyl CpG binding protein-2 (MeCP2) is an essential epigenetic regulator in human brain development. Rett syndrome, the primary disorder caused by mutations in the X-linked MECP2 gene, is characterized by a period of cognitive decline and development of hand stereotypies and seizures following an apparently normal early infancy. In addition, MECP2 mutations and duplications are observed in a spectrum of neurodevelopmental disorders, including severe neonatal encephalopathy, X-linked mental retardation, and autism, implicating MeCP2 as an essential regulator of postnatal brain development. In this review, we compare the mutation types and inheritance patterns of the human disorders associated with MECP2. In addition, we summarize the current understanding of MeCP2 as a central epigenetic regulator of activity-dependent synaptic maturation. As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies." @default.
• W2044763721 created "2016-06-24" @default.
• W2044763721 creator A5010417321 @default.
• W2044763721 creator A5051358401 @default.
• W2044763721 date "2010-03-24" @default.
• W2044763721 modified "2023-09-30" @default.
• W2044763721 title "The Role of MeCP2 in Brain Development and Neurodevelopmental Disorders" @default.
• W2044763721 cites W1486257535 @default.
• W2044763721 cites W1488115555 @default.
• W2044763721 cites W1559742681 @default.
• W2044763721 cites W1964159332 @default.
• W2044763721 cites W1971952955 @default.
• W2044763721 cites W1974814280 @default.
• W2044763721 cites W1980056577 @default.
• W2044763721 cites W1981495424 @default.
• W2044763721 cites W1985966348 @default.
• W2044763721 cites W1988559329 @default.
• W2044763721 cites W1988663056 @default.
• W2044763721 cites W1988794993 @default.
• W2044763721 cites W1994210488 @default.
• W2044763721 cites W1994974752 @default.
• W2044763721 cites W1999775510 @default.
• W2044763721 cites W2013655994 @default.
• W2044763721 cites W2018947009 @default.
• W2044763721 cites W2019264057 @default.
• W2044763721 cites W2021878605 @default.
• W2044763721 cites W2024159278 @default.
• W2044763721 cites W2033609439 @default.
• W2044763721 cites W2034432700 @default.
• W2044763721 cites W2035412136 @default.
• W2044763721 cites W2039276157 @default.
• W2044763721 cites W2049128446 @default.
• W2044763721 cites W2053919064 @default.
• W2044763721 cites W2055684815 @default.
• W2044763721 cites W2059180147 @default.
• W2044763721 cites W2072506631 @default.
• W2044763721 cites W2090571054 @default.
• W2044763721 cites W2092790576 @default.
• W2044763721 cites W2106863904 @default.
• W2044763721 cites W2110618683 @default.
• W2044763721 cites W2112193800 @default.
• W2044763721 cites W2113377321 @default.
• W2044763721 cites W2127311839 @default.
• W2044763721 cites W2137719949 @default.
• W2044763721 cites W2142772281 @default.
• W2044763721 cites W2146800857 @default.
• W2044763721 cites W2147268803 @default.
• W2044763721 cites W2149119305 @default.
• W2044763721 cites W2149522457 @default.
• W2044763721 cites W2155388782 @default.
• W2044763721 cites W2159580096 @default.
• W2044763721 cites W2161403252 @default.
• W2044763721 cites W2162961880 @default.
• W2044763721 cites W2167600834 @default.
• W2044763721 cites W2168814517 @default.
• W2044763721 cites W2172130553 @default.
• W2044763721 cites W2222864307 @default.
• W2044763721 cites W4233825908 @default.
• W2044763721 doi "https://doi.org/10.1007/s11920-010-0097-7" @default.
• W2044763721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847695" @default.
• W2044763721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20425298" @default.
• W2044763721 hasPublicationYear "2010" @default.
• W2044763721 type Work @default.
• W2044763721 sameAs 2044763721 @default.
• W2044763721 citedByCount "158" @default.
• W2044763721 countsByYear W20447637212012 @default.
• W2044763721 countsByYear W20447637212013 @default.
• W2044763721 countsByYear W20447637212014 @default.
• W2044763721 countsByYear W20447637212015 @default.
• W2044763721 countsByYear W20447637212016 @default.
• W2044763721 countsByYear W20447637212017 @default.
• W2044763721 countsByYear W20447637212018 @default.
• W2044763721 countsByYear W20447637212019 @default.
• W2044763721 countsByYear W20447637212020 @default.
• W2044763721 countsByYear W20447637212021 @default.
• W2044763721 countsByYear W20447637212022 @default.
• W2044763721 countsByYear W20447637212023 @default.
• W2044763721 crossrefType "journal-article" @default.
• W2044763721 hasAuthorship W2044763721A5010417321 @default.
• W2044763721 hasAuthorship W2044763721A5051358401 @default.
• W2044763721 hasBestOaLocation W20447637211 @default.
• W2044763721 hasConcept C104317684 @default.
• W2044763721 hasConcept C118552586 @default.
• W2044763721 hasConcept C127716648 @default.
• W2044763721 hasConcept C150194340 @default.
• W2044763721 hasConcept C169760540 @default.
• W2044763721 hasConcept C190727270 @default.
• W2044763721 hasConcept C205778803 @default.
• W2044763721 hasConcept C2777543196 @default.
• W2044763721 hasConcept C2778538070 @default.
• W2044763721 hasConcept C2778863441 @default.
• W2044763721 hasConcept C2779388368 @default.
• W2044763721 hasConcept C41091548 @default.
• W2044763721 hasConcept C54355233 @default.
• W2044763721 hasConcept C60644358 @default.
• W2044763721 hasConcept C6929976 @default.
• W2044763721 hasConcept C71924100 @default.
• W2044763721 hasConcept C86803240 @default.

• next