FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044767235> ?p ?o ?g. }

• W2044767235 endingPage "054109" @default.
• W2044767235 startingPage "054109" @default.
• W2044767235 abstract "Phytomolecules may chemically bind to scaffold materials for medical applications. The present study used an osteoconductive porous poly(l-lactide-co-glycolide)/tricalcium phosphate (PLGA/TCP) to incorporate an exogenous phytoestrogenic molecule icaritin to form a PLGA/TCP/icaritin composite scaffold material with potential slow release of icaritin during scaffold degradation. Accordingly, the present study was designed to investigate its in vitro degradation characteristics and the release pattern of icaritin at three different doses (74 mg, 7.4 mg and 0.74 mg per 100 g PLGA/TCP, i.e. in the PLGA/TCP/icaritin-H, -M and -L groups, respectively). A PLGA/TCP/icaritin porous composite scaffold was fabricated using a computer-controlled printing machine. The PLGA/TCP/icaritin scaffolds were incubated in saline at 37 °C for 12 weeks and the pure PLGA/TCP scaffold served as a control. During the 12 weeks in vitro degradation, the scaffolds in all four groups showed changes, including a decrease in weight, volume and pore size of the composite scaffold, while there was a decrease in acidity and an increase in Ca and lactic acid concentrations in the degradation medium, especially after 7 weeks. The rate of degradation was explained by the relationship with the content of icaritin incorporated into the scaffolds. The higher the icaritin content in the scaffolds, the slower the degradation could be observed during 12 weeks. After 12 weeks, the SEM showed that the surface of the PLGA/TCP and PLGA/TCP/icaritin-L groups was relatively smooth with a gradual decrease in number and size of the micropores, while the porous morphology on the surface of the PLGA/TCP/icaritin-M and PLGA/TCP/icaritin-H groups was partly maintained, accompanied by a decrease in phosphate (P) and calcium (Ca) contents at the surface. Though the mechanical property of the PLGA/TCP/icaritin scaffold decreased after degradation, its porous structure was maintained, which was essential for cell migration and ingrowth of newly regenerated tissues in vivo. The controlled release of icaritin from the composite scaffold reached about 70% of the incorporated icaritin into the degradation medium after 12 weeks. The above findings suggested that the structural and degradation properties of the porous composite PLGA/TCP/icaritin scaffold were dependent on icaritin concentrations. This innovative composite porous scaffold material developed in the present study may be used as a good scaffold material for enhancing bone repair, especially at high concentrations of icaritin. In vivo confirmation is, however, needed to substantiate our in vitro findings." @default.
• W2044767235 created "2016-06-24" @default.
• W2044767235 creator A5018820349 @default.
• W2044767235 creator A5027048963 @default.
• W2044767235 creator A5027537426 @default.
• W2044767235 creator A5036623415 @default.
• W2044767235 creator A5047157625 @default.
• W2044767235 creator A5048050257 @default.
• W2044767235 creator A5061836458 @default.
• W2044767235 creator A5070608096 @default.
• W2044767235 creator A5086264545 @default.
• W2044767235 creator A5086389738 @default.
• W2044767235 date "2010-09-28" @default.
• W2044767235 modified "2023-10-16" @default.
• W2044767235 title "Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin" @default.
• W2044767235 cites W1964985298 @default.
• W2044767235 cites W1967767102 @default.
• W2044767235 cites W1971053654 @default.
• W2044767235 cites W1983283949 @default.
• W2044767235 cites W1983685820 @default.
• W2044767235 cites W1987495583 @default.
• W2044767235 cites W1995801858 @default.
• W2044767235 cites W1995916543 @default.
• W2044767235 cites W2015513845 @default.
• W2044767235 cites W2016161594 @default.
• W2044767235 cites W2020498513 @default.
• W2044767235 cites W2022114520 @default.
• W2044767235 cites W2023782079 @default.
• W2044767235 cites W2023953000 @default.
• W2044767235 cites W2031297205 @default.
• W2044767235 cites W2032157866 @default.
• W2044767235 cites W2041558541 @default.
• W2044767235 cites W2043310171 @default.
• W2044767235 cites W2045865675 @default.
• W2044767235 cites W2049435279 @default.
• W2044767235 cites W2050171928 @default.
• W2044767235 cites W2050905519 @default.
• W2044767235 cites W2051560964 @default.
• W2044767235 cites W2055891425 @default.
• W2044767235 cites W2056112402 @default.
• W2044767235 cites W2057852412 @default.
• W2044767235 cites W2063014688 @default.
• W2044767235 cites W2066560561 @default.
• W2044767235 cites W2068952590 @default.
• W2044767235 cites W2070037821 @default.
• W2044767235 cites W2075543804 @default.
• W2044767235 cites W2076587760 @default.
• W2044767235 cites W2081482504 @default.
• W2044767235 cites W2082939276 @default.
• W2044767235 cites W2087230484 @default.
• W2044767235 cites W2092662468 @default.
• W2044767235 cites W2094125763 @default.
• W2044767235 cites W2094424086 @default.
• W2044767235 cites W2103116614 @default.
• W2044767235 cites W2113042424 @default.
• W2044767235 cites W2115349734 @default.
• W2044767235 cites W2142640723 @default.
• W2044767235 cites W2155562094 @default.
• W2044767235 cites W2159210886 @default.
• W2044767235 cites W2187880154 @default.
• W2044767235 cites W2192650118 @default.
• W2044767235 cites W2483860429 @default.
• W2044767235 cites W321482018 @default.
• W2044767235 cites W4211147424 @default.
• W2044767235 cites W4320800983 @default.
• W2044767235 doi "https://doi.org/10.1088/1748-6041/5/5/054109" @default.
• W2044767235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20876954" @default.
• W2044767235 hasPublicationYear "2010" @default.
• W2044767235 type Work @default.
• W2044767235 sameAs 2044767235 @default.
• W2044767235 citedByCount "38" @default.
• W2044767235 countsByYear W20447672352012 @default.
• W2044767235 countsByYear W20447672352013 @default.
• W2044767235 countsByYear W20447672352014 @default.
• W2044767235 countsByYear W20447672352015 @default.
• W2044767235 countsByYear W20447672352016 @default.
• W2044767235 countsByYear W20447672352017 @default.
• W2044767235 countsByYear W20447672352018 @default.
• W2044767235 countsByYear W20447672352019 @default.
• W2044767235 countsByYear W20447672352020 @default.
• W2044767235 countsByYear W20447672352022 @default.
• W2044767235 countsByYear W20447672352023 @default.
• W2044767235 crossrefType "journal-article" @default.
• W2044767235 hasAuthorship W2044767235A5018820349 @default.
• W2044767235 hasAuthorship W2044767235A5027048963 @default.
• W2044767235 hasAuthorship W2044767235A5027537426 @default.
• W2044767235 hasAuthorship W2044767235A5036623415 @default.
• W2044767235 hasAuthorship W2044767235A5047157625 @default.
• W2044767235 hasAuthorship W2044767235A5048050257 @default.
• W2044767235 hasAuthorship W2044767235A5061836458 @default.
• W2044767235 hasAuthorship W2044767235A5070608096 @default.
• W2044767235 hasAuthorship W2044767235A5086264545 @default.
• W2044767235 hasAuthorship W2044767235A5086389738 @default.
• W2044767235 hasConcept C104779481 @default.
• W2044767235 hasConcept C136229726 @default.
• W2044767235 hasConcept C159985019 @default.
• W2044767235 hasConcept C185592680 @default.
• W2044767235 hasConcept C192562407 @default.

• next