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- W2044773067 abstract "1 Fluvoxamine maleate is a compound from the series of 2- aminoethyloximethers of aralkylketones which possesses marked inhibition effects on 5-hydroxytryptamine (5-HT) uptake by blood platelets and brain synaptosomes. In contrast, it has no effect on noradrenaline uptake processes. 2 Fluvoxamine is completely absorbed in rats and dogs; the main metabolic path was similar in rat, dog, hamster, mouse and rabbit. The metabolites of fluvoxamine are inactive with regard to aminergic uptake processes. 3 Fluvoxamine is neither sedative nor stimulating, shows a very low cardiotoxic effect and no affinity for the cholinergic receptor. On the basis of the pharmacological profile, a highly favourable therapeutic ratio of antidepressant effects vs disturbing side-effects is predicted." @default.
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- W2044773067 date "1983-06-01" @default.
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- W2044773067 title "Review of the animal pharmacology and pharmacokinetics of fluvoxamine." @default.
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- W2044773067 doi "https://doi.org/10.1111/j.1365-2125.1983.tb02125.x" @default.
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