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- W2044775897 abstract "Mucosal dendritic cells affect immune responses through secretion of cytokines and exposure of naïve B- and T-lymphocytes to foreign matter as antigen presenting cells (APCs). APC in oral tissues may play a role in the development of local and secretory immune responses [Crit. Rev. Oral Biol. Med. 7 (1996) 36]. Previous studies have shown that APC are present in the interstitial tissues of rat salivary glands [Arch. Oral Biol. 40 (1995) 1015]. This study sought to further define the distribution of APC in salivary glands. The major glands and ducts of male Sprague-Dawley and Wistar rats were fixed with 4% paraformaldehyde and prepared for immunofluorescence and pre- and post-embedding immunoelectron microscopy. Monoclonal antibodies to the dendritic cell marker Ia antigen (OX-6 antibody), monocyte lineage cytoplasmic antigen (ED-1), and resident tissue macrophage antigen (ED-2) were visualized with FITC-conjugated secondary antibodies for light microscopy and HRP- and gold-labelled secondary antibodies for electron microscopy. Light microscopy revealed numerous OX-6-positive cells with branching processes in the epithelium of striated and excretory ducts of both rat strains, as well as in the connective tissue stroma. ED-1-positive cells had a similar distribution but exhibited a more compact shape with fewer processes. ED-2-positive cells were found only in the connective tissue. Acinar and duct epithelial cells were unreactive. Electron microscopy confirmed that both OX-6-positive and ED-1-positive, non-epithelial cells were present within the duct epithelium. The presence of APC in the duct epithelium suggests that these ducts may be exposed to antigens, possibly by retrograde access from the oral cavity, and that APC located in the salivary gland epithelium may participate in local immune responses." @default.
- W2044775897 created "2016-06-24" @default.
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- W2044775897 date "2003-10-01" @default.
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- W2044775897 title "Immunohistochemical identification of antigen presenting cells in rat salivary glands" @default.
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- W2044775897 doi "https://doi.org/10.1016/s0003-9969(03)00133-x" @default.
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