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- W2044776625 abstract "Candida albicans is a diploid yeast with a dimorphic life history. It exists commensally in many healthy humans but becomes a potent pathogen in immunocompromised hosts. The underlying genetic mechanisms by which C. albicans switches from a commensal to a pathogenic form in the host are not well understood. To study the evolution of virulence in mammalian hosts, we used GAL1 as selectable marker system that allows for both positive and negative selection in selective media. We show that the deletion of one or both copies of GAL1 in the C. albicans genome does not change virulence in a systemic mouse model. We obtained estimates for the frequency of mitotic recombination at the GAL1 locus during systemic infection. Our observations suggest that genetic changes such as mitotic recombination and gene conversion occur at a high enough frequency to be important in the transition of C. albicans from a commensal to a pathogenic organism." @default.
- W2044776625 created "2016-06-24" @default.
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- W2044776625 date "2003-06-01" @default.
- W2044776625 modified "2023-10-16" @default.
- W2044776625 title "A system for studying genetic changes in Candida albicans during infection" @default.
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- W2044776625 doi "https://doi.org/10.1016/s1087-1845(02)00585-6" @default.
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