FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044776710> ?p ?o ?g. }

• W2044776710 endingPage "333" @default.
• W2044776710 startingPage "327" @default.
• W2044776710 abstract "Endothelial activation is an important step in atherogenesis. In addition to established cardiovascular risk factors, such as hypercholesterolemia, hypertension, diabetes mellitus, and homocysteinemia, high plasma levels of triglyceride-rich lipoproteins may be an important cause of endothelial activation as well. Free fatty acids hydrolyzed from core triglycerides of these particles can exert both pro- and anti-inflammatory effects on the vascular wall. [omega ]-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to inhibit cytokine-induced endothelial activation. In contrast, we and others have previously shown that the [omega ]-6 fatty acid linoleate activates transcription factor nuclear factor-[kappa ]B (NF-[kappa ]B) in endothelial cells. In this study, we show that linoleic acid stimulates vascular adhesion molecule-1 (VCAM-1) protein and mRNA expression in cultured human endothelial cells, as assessed by immunoflourescence and Northern blotting. Release of shedded soluble VCAM-1 from cultured human endothelial cells was also increased by the addition of linoleic acid, as determined by enzyme-linked immunosorbent assay (ELISA). By use of cultured rat aortic endothelial cells transfected with an I[kappa ]B super-repressor ([Delta ]N2 cells), we provide evidence that NF-[kappa ]B signalling is required in the linoleic acid-induced VCAM-1 expression in endothelial cells, whereas other transcription factors appear to be involved in the increased endothelial plasminogen activator inhibitor-1 (PAI-1) production in response to linoleic acid. These findings suggest that diets rich in linoleic acid may be proinflammatory and thus atherogenic by activating vascular endothelial cells." @default.
• W2044776710 created "2016-06-24" @default.
• W2044776710 creator A5004112428 @default.
• W2044776710 creator A5015346279 @default.
• W2044776710 creator A5021276063 @default.
• W2044776710 creator A5028094654 @default.
• W2044776710 creator A5043556773 @default.
• W2044776710 creator A5057919911 @default.
• W2044776710 creator A5069317017 @default.
• W2044776710 creator A5083861048 @default.
• W2044776710 creator A5084479574 @default.
• W2044776710 date "2002-03-01" @default.
• W2044776710 modified "2023-10-01" @default.
• W2044776710 title "Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-[kappa ]B activation" @default.
• W2044776710 cites W1544412212 @default.
• W2044776710 cites W1559886422 @default.
• W2044776710 cites W1862623267 @default.
• W2044776710 cites W1895462365 @default.
• W2044776710 cites W1983086379 @default.
• W2044776710 cites W1983835495 @default.
• W2044776710 cites W1985836457 @default.
• W2044776710 cites W1995310791 @default.
• W2044776710 cites W2021071121 @default.
• W2044776710 cites W2035280687 @default.
• W2044776710 cites W2037548392 @default.
• W2044776710 cites W2040585929 @default.
• W2044776710 cites W2057647664 @default.
• W2044776710 cites W2073033133 @default.
• W2044776710 cites W2082162145 @default.
• W2044776710 cites W2083216589 @default.
• W2044776710 cites W2083217753 @default.
• W2044776710 cites W2097103756 @default.
• W2044776710 cites W2104852889 @default.
• W2044776710 cites W2120871101 @default.
• W2044776710 cites W2123148431 @default.
• W2044776710 cites W2125008605 @default.
• W2044776710 cites W2128678876 @default.
• W2044776710 cites W2131232949 @default.
• W2044776710 cites W2134771161 @default.
• W2044776710 cites W2135859412 @default.
• W2044776710 cites W2140424939 @default.
• W2044776710 cites W2141192859 @default.
• W2044776710 cites W2144352269 @default.
• W2044776710 cites W2154519394 @default.
• W2044776710 cites W2155024223 @default.
• W2044776710 cites W2272657653 @default.
• W2044776710 cites W2315929780 @default.
• W2044776710 doi "https://doi.org/10.1053/meta.2002.29963" @default.
• W2044776710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11887169" @default.
• W2044776710 hasPublicationYear "2002" @default.
• W2044776710 type Work @default.
• W2044776710 sameAs 2044776710 @default.
• W2044776710 citedByCount "55" @default.
• W2044776710 countsByYear W20447767102012 @default.
• W2044776710 countsByYear W20447767102013 @default.
• W2044776710 countsByYear W20447767102014 @default.
• W2044776710 countsByYear W20447767102015 @default.
• W2044776710 countsByYear W20447767102018 @default.
• W2044776710 countsByYear W20447767102019 @default.
• W2044776710 countsByYear W20447767102021 @default.
• W2044776710 countsByYear W20447767102022 @default.
• W2044776710 crossrefType "journal-article" @default.
• W2044776710 hasAuthorship W2044776710A5004112428 @default.
• W2044776710 hasAuthorship W2044776710A5015346279 @default.
• W2044776710 hasAuthorship W2044776710A5021276063 @default.
• W2044776710 hasAuthorship W2044776710A5028094654 @default.
• W2044776710 hasAuthorship W2044776710A5043556773 @default.
• W2044776710 hasAuthorship W2044776710A5057919911 @default.
• W2044776710 hasAuthorship W2044776710A5069317017 @default.
• W2044776710 hasAuthorship W2044776710A5083861048 @default.
• W2044776710 hasAuthorship W2044776710A5084479574 @default.
• W2044776710 hasConcept C123012128 @default.
• W2044776710 hasConcept C126322002 @default.
• W2044776710 hasConcept C134018914 @default.
• W2044776710 hasConcept C16224149 @default.
• W2044776710 hasConcept C164027704 @default.
• W2044776710 hasConcept C185592680 @default.
• W2044776710 hasConcept C19038510 @default.
• W2044776710 hasConcept C202751555 @default.
• W2044776710 hasConcept C203014093 @default.
• W2044776710 hasConcept C2776091944 @default.
• W2044776710 hasConcept C2776246508 @default.
• W2044776710 hasConcept C2776914184 @default.
• W2044776710 hasConcept C2776992346 @default.
• W2044776710 hasConcept C2777171753 @default.
• W2044776710 hasConcept C2780809830 @default.
• W2044776710 hasConcept C2780972559 @default.
• W2044776710 hasConcept C543025807 @default.
• W2044776710 hasConcept C55493867 @default.
• W2044776710 hasConcept C71924100 @default.
• W2044776710 hasConcept C86803240 @default.
• W2044776710 hasConcept C95444343 @default.
• W2044776710 hasConceptScore W2044776710C123012128 @default.
• W2044776710 hasConceptScore W2044776710C126322002 @default.
• W2044776710 hasConceptScore W2044776710C134018914 @default.
• W2044776710 hasConceptScore W2044776710C16224149 @default.
• W2044776710 hasConceptScore W2044776710C164027704 @default.
• W2044776710 hasConceptScore W2044776710C185592680 @default.

• next