FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044776881> ?p ?o ?g. }

• W2044776881 endingPage "219" @default.
• W2044776881 startingPage "207" @default.
• W2044776881 abstract "Trappin-2/Elafin is a serine protease inhibitor that plays a major role as an anti-inflammatory mediator at mucosal surfaces. In addition, Trappin-2/Elafin has antibacterial activity against Gram-positive and Gram-negative bacterial and fungal pathogens. In this study we examined the production of Trappin-2/Elafin by epithelial cells from the human upper and lower female reproductive tract as well as its activity as an anti-human immunodeficiency virus (HIV)-1 molecule. We found that primary uterine, Fallopian tube, cervical and ectocervical epithelial cells produce Trappin-2/Elafin constitutively and that production of Trappin-2/Elafin is enhanced following stimulation with Poly(I:C), especially by the uterine cells. Given the presence of Trappin-2/Elafin in the reproductive tract, we tested the ability of recombinant Trappin-2/Elafin to inhibit HIV-1, an important sexually transmitted pathogen. We found that recombinant Trappin-2/Elafin was able to inhibit both T-cell-tropic X4/IIIB and macrophage-tropic R5/BaL HIV-1 in a dose-dependent manner. The inhibitory activity was observed when virus was incubated with Trappin-2/Elafin but not when Trappin-2/Elafin was added to cells either before infection or after infection. This suggests that the mechanism of inhibition is likely to be a direct interaction between HIV-1 and Trappin-2/Elafin. Additionally, we measured the levels of secreted Trappin-2/Elafin in cervico-vaginal lavages (CVL) from both HIV-positive and HIV-negative women and found that average levels of secreted Trappin-2/Elafin were higher in the CVL from HIV-negative women, although the values did not reach statistical significance. We also found that women at the secretory phase of the menstrual cycle produced more Trappin-2/Elafin in CVL relative to women at the proliferative phase of the menstrual cycle. Our data suggest that Trappin-2/Elafin might be an important endogenous microbicide of the female reproductive tract that is protective against HIV-1." @default.
• W2044776881 created "2016-06-24" @default.
• W2044776881 creator A5003141492 @default.
• W2044776881 creator A5006144681 @default.
• W2044776881 creator A5017248220 @default.
• W2044776881 creator A5025150770 @default.
• W2044776881 creator A5061094934 @default.
• W2044776881 creator A5061114731 @default.
• W2044776881 date "2010-02-01" @default.
• W2044776881 modified "2023-09-30" @default.
• W2044776881 title "Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract" @default.
• W2044776881 cites W146739493 @default.
• W2044776881 cites W1564804029 @default.
• W2044776881 cites W1599057242 @default.
• W2044776881 cites W1628777611 @default.
• W2044776881 cites W1751768505 @default.
• W2044776881 cites W1797701563 @default.
• W2044776881 cites W1947610403 @default.
• W2044776881 cites W1959149464 @default.
• W2044776881 cites W1968444539 @default.
• W2044776881 cites W1973996978 @default.
• W2044776881 cites W1979258089 @default.
• W2044776881 cites W1984276265 @default.
• W2044776881 cites W1986895898 @default.
• W2044776881 cites W1991521290 @default.
• W2044776881 cites W1994566416 @default.
• W2044776881 cites W1997490590 @default.
• W2044776881 cites W2001592513 @default.
• W2044776881 cites W2001988706 @default.
• W2044776881 cites W2006346430 @default.
• W2044776881 cites W2006448972 @default.
• W2044776881 cites W2010213320 @default.
• W2044776881 cites W2011003032 @default.
• W2044776881 cites W2015324997 @default.
• W2044776881 cites W2017785622 @default.
• W2044776881 cites W2024249553 @default.
• W2044776881 cites W2025837117 @default.
• W2044776881 cites W2028110266 @default.
• W2044776881 cites W2038675754 @default.
• W2044776881 cites W2044518018 @default.
• W2044776881 cites W2049102021 @default.
• W2044776881 cites W2052553326 @default.
• W2044776881 cites W2055200825 @default.
• W2044776881 cites W2055551548 @default.
• W2044776881 cites W2057023184 @default.
• W2044776881 cites W2064258123 @default.
• W2044776881 cites W2066261417 @default.
• W2044776881 cites W2066971931 @default.
• W2044776881 cites W2070112527 @default.
• W2044776881 cites W2071830962 @default.
• W2044776881 cites W2074533925 @default.
• W2044776881 cites W2075201634 @default.
• W2044776881 cites W2078399145 @default.
• W2044776881 cites W2082249057 @default.
• W2044776881 cites W2087658066 @default.
• W2044776881 cites W2093717452 @default.
• W2044776881 cites W2096438315 @default.
• W2044776881 cites W2096841521 @default.
• W2044776881 cites W2099331224 @default.
• W2044776881 cites W2113646062 @default.
• W2044776881 cites W2123579792 @default.
• W2044776881 cites W2126728363 @default.
• W2044776881 cites W2127986325 @default.
• W2044776881 cites W2143935360 @default.
• W2044776881 cites W2146478787 @default.
• W2044776881 cites W2149937578 @default.
• W2044776881 cites W2151730419 @default.
• W2044776881 cites W2153865080 @default.
• W2044776881 cites W2155621515 @default.
• W2044776881 cites W2159833823 @default.
• W2044776881 cites W2160226661 @default.
• W2044776881 cites W2162118074 @default.
• W2044776881 cites W2165032352 @default.
• W2044776881 cites W2168400885 @default.
• W2044776881 cites W2168479827 @default.
• W2044776881 cites W2334814171 @default.
• W2044776881 doi "https://doi.org/10.1111/j.1365-2567.2009.03165.x" @default.
• W2044776881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2814463" @default.
• W2044776881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19824918" @default.
• W2044776881 hasPublicationYear "2010" @default.
• W2044776881 type Work @default.
• W2044776881 sameAs 2044776881 @default.
• W2044776881 citedByCount "106" @default.
• W2044776881 countsByYear W20447768812012 @default.
• W2044776881 countsByYear W20447768812013 @default.
• W2044776881 countsByYear W20447768812014 @default.
• W2044776881 countsByYear W20447768812015 @default.
• W2044776881 countsByYear W20447768812016 @default.
• W2044776881 countsByYear W20447768812017 @default.
• W2044776881 countsByYear W20447768812018 @default.
• W2044776881 countsByYear W20447768812019 @default.
• W2044776881 countsByYear W20447768812020 @default.
• W2044776881 countsByYear W20447768812021 @default.
• W2044776881 countsByYear W20447768812022 @default.
• W2044776881 countsByYear W20447768812023 @default.
• W2044776881 crossrefType "journal-article" @default.
• W2044776881 hasAuthorship W2044776881A5003141492 @default.
• W2044776881 hasAuthorship W2044776881A5006144681 @default.

• next