FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044777772> ?p ?o ?g. }

• W2044777772 abstract "As neurons extend projections, such as axons, toward their targets, they receive signals from the targets. The sensory nerves of the trigeminal ganglia that innervate the face serve as a useful system to study both axonal targeting and neuronal fate specification (see Takatoh and Wang). Ji and Jaffrey isolated embryonic rat trigeminal ganglia neurons and cultured them in specialized chambers that enabled analysis of the axons separately from the cell bodies. Axonal application of bone morphogenetic protein 4 (BMP4), which is produced by the target epithelium of the maxillary and ophthalmic, but not the mandibular, regions of the face, produced an increase in the abundance of nuclear phosphorylated SMAD1, 5, and 8 (known targets of BMP4 signaling) and induction of a BMP4 target gene, Tbx3 . This BMP4 response was prevented by inhibition of retrograde signaling by blocking the activity of the molecular motor protein dynein in the axons or by application to the cell body of an inhibitor of the BMP4 receptor, suggesting that retrograde transport of BMP4 and its receptor contributed to this SMAD signal in the cell body. Retrograde signaling, but not retrograde transport of BMP4, was blocked by application of protein synthesis inhibitors to the axons, suggesting that axonally localized translation contributed to the BMP4 signal. Transcripts encoding SMAD1, 5, and 8 were detected in the axons of the isolated neurons and in the axons of all trigeminal neurons in embryonic rats; however, in vivo the proteins were only detected in the axons innervating the ophthalmic and maxillary regions and not in those for the mandibular region. Brain-derived neurotrophin factor (BDNF) is a specific factor produced by the ophthalmic and maxillary target epithelium, and application of BDNF to the axons of the cultured neurons stimulated the synthesis of SMAD1, 5, and 8. By pretreating the cultured neurons with neurotrophin-free media, the authors showed that the BMP4 retrograde signal required both BDNF and BMP4 to produce an increase in nuclear phosphorylated SMADs in the cell body. The importance of BDNF for trigeminal nerve specification, but not axonal growth, was verified with mice genetically deficient in BDNF, which eliminated the differences in SMAD1, 5, and 8 abundance; nuclear phosphorylated SMADs; and Tbx3 abundance between the ophthalmic and maxillary nerves and the mandibular nerves. Thus, BDNF appears to prime the axons for receiving the BMP4 signal by stimulating the production of the SMADs in the axons to promote retrograde BMP4 signals. S.-J. Ji, S. R. Jaffrey, Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 74 , 95–107 (2012). [Online Journal] J. Takatoh, F. Wang, Axonally translated SMADs link up BDNF and retrograde BMP signaling. Neuron 74 , 3–5 (2012). [Online Journal]" @default.
• W2044777772 created "2016-06-24" @default.
• W2044777772 creator A5056409786 @default.
• W2044777772 date "2012-04-17" @default.
• W2044777772 modified "2023-09-26" @default.
• W2044777772 title "Local Synthesis for Retrograde Signaling" @default.
• W2044777772 doi "https://doi.org/10.1126/scisignal.2003139" @default.
• W2044777772 hasPublicationYear "2012" @default.
• W2044777772 type Work @default.
• W2044777772 sameAs 2044777772 @default.
• W2044777772 citedByCount "0" @default.
• W2044777772 crossrefType "journal-article" @default.
• W2044777772 hasAuthorship W2044777772A5056409786 @default.
• W2044777772 hasConcept C104317684 @default.
• W2044777772 hasConcept C105702510 @default.
• W2044777772 hasConcept C145103041 @default.
• W2044777772 hasConcept C169760540 @default.
• W2044777772 hasConcept C194082555 @default.
• W2044777772 hasConcept C2776352249 @default.
• W2044777772 hasConcept C2781080636 @default.
• W2044777772 hasConcept C2781316418 @default.
• W2044777772 hasConcept C31507581 @default.
• W2044777772 hasConcept C55493867 @default.
• W2044777772 hasConcept C62478195 @default.
• W2044777772 hasConcept C70192387 @default.
• W2044777772 hasConcept C86803240 @default.
• W2044777772 hasConcept C94487597 @default.
• W2044777772 hasConcept C95444343 @default.
• W2044777772 hasConceptScore W2044777772C104317684 @default.
• W2044777772 hasConceptScore W2044777772C105702510 @default.
• W2044777772 hasConceptScore W2044777772C145103041 @default.
• W2044777772 hasConceptScore W2044777772C169760540 @default.
• W2044777772 hasConceptScore W2044777772C194082555 @default.
• W2044777772 hasConceptScore W2044777772C2776352249 @default.
• W2044777772 hasConceptScore W2044777772C2781080636 @default.
• W2044777772 hasConceptScore W2044777772C2781316418 @default.
• W2044777772 hasConceptScore W2044777772C31507581 @default.
• W2044777772 hasConceptScore W2044777772C55493867 @default.
• W2044777772 hasConceptScore W2044777772C62478195 @default.
• W2044777772 hasConceptScore W2044777772C70192387 @default.
• W2044777772 hasConceptScore W2044777772C86803240 @default.
• W2044777772 hasConceptScore W2044777772C94487597 @default.
• W2044777772 hasConceptScore W2044777772C95444343 @default.
• W2044777772 hasLocation W20447777721 @default.
• W2044777772 hasOpenAccess W2044777772 @default.
• W2044777772 hasPrimaryLocation W20447777721 @default.
• W2044777772 hasRelatedWork W1603257718 @default.
• W2044777772 hasRelatedWork W1667125429 @default.
• W2044777772 hasRelatedWork W1964784675 @default.
• W2044777772 hasRelatedWork W1966541949 @default.
• W2044777772 hasRelatedWork W1968724315 @default.
• W2044777772 hasRelatedWork W1971219322 @default.
• W2044777772 hasRelatedWork W1973409138 @default.
• W2044777772 hasRelatedWork W1986998447 @default.
• W2044777772 hasRelatedWork W2029942070 @default.
• W2044777772 hasRelatedWork W2055240694 @default.
• W2044777772 hasRelatedWork W2077741941 @default.
• W2044777772 hasRelatedWork W2094825037 @default.
• W2044777772 hasRelatedWork W2106765135 @default.
• W2044777772 hasRelatedWork W2131711809 @default.
• W2044777772 hasRelatedWork W2139211316 @default.
• W2044777772 hasRelatedWork W2146229756 @default.
• W2044777772 hasRelatedWork W2275696014 @default.
• W2044777772 hasRelatedWork W2928435155 @default.
• W2044777772 hasRelatedWork W3029085830 @default.
• W2044777772 hasRelatedWork W3125244673 @default.
• W2044777772 isParatext "false" @default.
• W2044777772 isRetracted "false" @default.
• W2044777772 magId "2044777772" @default.
• W2044777772 workType "article" @default.