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- W2044778043 abstract "The effect of oligomycin + 2-deoxyglucose (2-DG), 1-fluoro-2,4-dinitrobenzene (FDNB) and 2,4-dinitrophenol (DNP) on the 45Ca exchange of rat cardiac cells in culture was investigated. All three inhibitors caused the cessation of spontaneous beating of the cells with a concomitant decrease of ATP to 70 to 80% of control value. It is not known which step in the spontaneous rhythmic contraction is sensitive to the decrease of ATP and therefore it was of interest to study the 45Ca exchange as the possible senstive site. A previously described method for direct counting of cellular activity was used. In the absence of the inhibitors the cellular washout curves were resolved into three components. The most rapid component represents residual labeling solution, the next component (λ = 1.02 min−1) represents a portion of cellular Ca2+, while the last slow component seems to involve mitochondrial binding of Ca2+. In the presence of oligomycin + 2-DG and FDNB, the washout patterns were the same as in the control cells. The cessation of beating in the presence of these inhibitors therefore cannot be interpreted in terms of any effect on Ca2+ exchange. However, in the presence of DNP, the washout curve could be resolved into two phases only, the fast extracellular and the fast cellular phases were present but the slowest third phase was missing and no 45Ca uptake corresponding to the slowly exchanging phase of the cell was detected. This result gives support to the interpretation that the third phase of the washout pattern represents predominantly mitochondrial exchange." @default.
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- W2044778043 title "The effect of inhibitors on the calcium exchange of heart cells in tissue culture" @default.
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- W2044778043 doi "https://doi.org/10.1016/0022-2828(70)90040-4" @default.
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